The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study.

Autor: Sandes-Freitas TV; Departamento de Medicina Clínica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.; Serviço de Nefrologia e Transplante Renal, Hospital Universitário Walter Cantídio, Fortaleza, Ceará, Brazil.; Setor de Transplantes, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil., Moura LR; Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, São Paulo, Brazil.; Nephrology Division, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Carvalho DRBM; Centro Avançado de Transplante de Órgãos e Tecidos, Hospital São Francisco na Providência de Deus, Rio de Janeiro, Rio de Janeiro, Brazil., Garcia VD; Centro de Transplantes, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Modelli de Andrade LG; Departamento de Medicina Interna, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil., Mazzali M; Disciplina de Nefrologia, Faculdade de Ciencias Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Manfro RC; Serviço de Nefrologia, Unidade de Transplante Renal, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Deboni LM; Serviço de Transplante, Hospital Municipal São José de Joinville, Fundação Pró-Rim, Joinville, Santa Catarina, Brazil., Davi-Neto E; Serviço de Transplante renal, Hospital de Clínicas da Universidade de São Paulo, São Paulo, São Paulo, Brazil., Oliveira CMC; Serviço de Nefrologia e Transplante Renal, Hospital Universitário Walter Cantídio, Fortaleza, Ceará, Brazil., Cavalcanti FCB; Unidade de Nefrologia, Real Hospital Português de Beneficência em Pernambuco, Recife, Pernambuco, Brazil., Madeira RL; Unidade de Transplante Renal, Hospital Felício Rocho, Belo Horizonte, Minas Gerais, Brazil., Esmeraldo RM; Setor de Transplantes, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil., Simão DR; Departamento de Transplante Renal, Hospital Santa Isabel, Blumenau, Santa Catarina, Brazil., Meira ACG; Unidade de Transplante Renal, Santa Casa Montes Claros, Montes Claros, Minas Gerais, Brazil., Ferreira GF; Unidade de Transplante Renal, Santa Casa de Misericórdia de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil., Lasmar M; Serviço de Nefrologia, Hospital Universitário Ciências Médicas, Belo Horizonte, Minas Gerais, Brazil., Bignelli AT; Unidade de Transplante Renal, Hospital Universitário Cajuru, Curitiba, Paraná, Brazil., Pacheco-Silva A; Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil., Medina Pestana J; Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, São Paulo, Brazil.; Nephrology Division, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., Tedesco Silva H; Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, São Paulo, Brazil.; Nephrology Division, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jul 05; Vol. 19 (7), pp. e0306056. Date of Electronic Publication: 2024 Jul 05 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0306056
Abstrakt: This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival.
Competing Interests: The study received financial support from Contatti Comercio e Representações Ltda, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
(Copyright: © 2024 Sandes-Freitas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje