Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.

Autor: Arenaza-Urquijo EM; Environment and Health Over the Life Course Programme, Climate, Air Pollution, Nature and Urban Health Programme, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; University of Pompeu Fabra, Barcelona, Barcelona, Spain., Boyle R; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Casaletto K; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, USA., Anstey KJ; University of New South Wales Ageing Futures Institute, Sydney, New South Wales, Australia.; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sidney, New South Wales, Australia., Vila-Castelar C; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Colverson A; University of Florida Center for Arts in Medicine Interdisciplinary Research Lab, University of Florida, Center of Arts in Medicine, Gainesville, Florida, USA., Palpatzis E; Environment and Health Over the Life Course Programme, Climate, Air Pollution, Nature and Urban Health Programme, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; University of Pompeu Fabra, Barcelona, Barcelona, Spain., Eissman JM; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kheng Siang Ng T; Rush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA., Raghavan S; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Akinci M; Environment and Health Over the Life Course Programme, Climate, Air Pollution, Nature and Urban Health Programme, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; University of Pompeu Fabra, Barcelona, Barcelona, Spain., Vonk JMJ; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, USA., Machado LS; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal Do Rio Grande Do Sul, Farroupilha, Porto Alegre, Brazil., Zanwar PP; Jefferson College of Population Health, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; The Network on Life Course and Health Dynamics and Disparities, University of Southern California, Los Angeles, California, USA., Shrestha HL; Laurentian University, Sudbury, Ontario, Canada., Wagner M; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Tamburin S; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Sohrabi HR; Centre for Healthy Ageing, Health Future Institute, Murdoch University, Murdoch, Western Australia, Australia.; School of Psychology, Murdoch University, Murdoch, Western Australia, Australia., Loi S; Neuropsychiatry Centre, Royal Melbourne Hospital, Parkville, Victoria, Australia.; Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia., Bartrés-Faz D; Department of Medicine, Faculty of Medicine and Health Sciences & Institut de Neurociències, University of Barcelona, Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques (IDIBAPS), Barcelona, Barcelona, Spain.; Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autónoma de Barcelona, Badalona, Barcelona, Spain., Dubal DB; Department of Neurology and Weill Institute of Neurosciences, University of California, San Francisco, San Francisco, California, USA.; Biomedical and Neurosciences Graduate Programs, University of California, San Francisco, San Francisco, California, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Okonkwo O; Alzheimer's Disease Research Center and Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Ewers M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Buckley RF; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Aug; Vol. 20 (8), pp. 5695-5719. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1002/alz.13844
Abstrakt: Sex and gender-biological and social constructs-significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular disease) which ultimately shape cognitive trajectories. Understanding the interplay of these factors is central to understanding resilience and resistance mechanisms explaining maintained cognitive function and reduced pathology accumulation in aging and AD. In this narrative review, the ADDRESS! Special Interest Group (Alzheimer's Association) adopted a multidisciplinary approach to provide the foundations and recommendations for future research into sex- and gender-specific drivers of resilience, including a sex/gender-oriented review of risk factors, genetics, AD and non-AD pathologies, brain structure and function, and animal research. We urge the field to adopt a sex/gender-aware approach to resilience to advance our understanding of the intricate interplay of biological and social determinants and consider sex/gender-specific resilience throughout disease stages. HIGHLIGHTS: Sex differences in resilience to cognitive decline vary by age and cognitive status. Initial evidence supports sex-specific distinctions in brain pathology. Findings suggest sex differences in the impact of pathology on cognition. There is a sex-specific change in resilience in the transition to clinical stages. Gender and sex factors warrant study: modifiable, immune, inflammatory, and vascular.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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