Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells.

Autor: Wang J; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.; CAS Key Laboratory of Marine Environmental Corrosion and Bio-Fouling, Institute of Oceanology, China Academy of Sciences, Qingdao, 266071, China., Li P; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China., Zhang R; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China., Zhang M; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China., Wang C; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China., Zhao K; Department of Breast Surgery, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266042, China., Wang J; CAS Key Laboratory of Marine Environmental Corrosion and Bio-Fouling, Institute of Oceanology, China Academy of Sciences, Qingdao, 266071, China., Wang N; CAS Key Laboratory of Marine Environmental Corrosion and Bio-Fouling, Institute of Oceanology, China Academy of Sciences, Qingdao, 266071, China., Xing D; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Oct; Vol. 20 (40), pp. e2401772. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1002/smll.202401772
Abstrakt: Flexibility of nanomaterials is challenging but worthy to tune for biomedical applications. Biocompatible silica nanomaterials are under extensive exploration but are rarely observed to exhibit flexibility despite the polymeric nature. Herein, a facile one-step route is reported to ultrathin flexible silica nanosheets (NSs), whose low thickness and high diameter-to-thickness ratio enables folding. Thickness and diameter can be readily tuned to enable controlled flexibility. Mechanism study reveals that beyond the commonly used surfactant, the "uncommon" one bearing two hydrophobic tails play a guiding role in producing sheeted/layered/shelled structures, while addition of ethanol appropriately relieved the strong interfacial tension of the assembled surfactants, which will otherwise produce large curled sheeted structures. With these ultrathin NSs, it is further shown that the cellular preference for particle shape and rigidity is highly dependent on surface chemistry of nanoparticles: under high particle-cell affinity, NSs, and especially the flexible ones will be preferred by mammalian cells for internalization or attachment, while this preference is basically invalid when the affinity is low. Therefore, properties of the ultrathin silica NSs can be effectively expanded and empowered by surface chemistry to realize improved bio-sensing or drug delivery.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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