Hypereosinophilia and Left Ventricular Thrombus: A Case Report and Literature Review.

Autor:	Khachatryan A; Department of Internal Medicine, University of Maryland Medical Center, Midtown Campus, Baltimore, USA., Harutyunyan H; Department of Internal Medicine, Maimonides Medical Center, New York, USA., Psotka M; Department of Advanced Heart Failure and Transplant Cardiology, Inova Fairfax Medical Campus, Falls Church, USA., Batikyan A; Department of Internal Medicine, North Central Bronx Hospital, New York, USA., Cinar T; Department of Internal Medicine, University of Maryland Medical Center, Midtown Campus, Baltimore, USA., Khorsandi M; Department of Cardiology, Johns Hopkins University, Baltimore, USA., Alejandro J; Department of Internal Medicine, University of Maryland Medical Center, Midtown Campus, Baltimore, USA., Tamazyan V; Department of Internal Medicine, Maimonides Medical Center, New York, USA., Sargsyan M; Department of Cardiology, 'Heratsi' Hospital Complex № 1, Yerevan, ARM.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 04; Vol. 16 (6), pp. e61674. Date of Electronic Publication: 2024 Jun 04 (Print Publication: 2024).
DOI:	10.7759/cureus.61674
Abstrakt:	Left ventricular thrombus (LVT) has historically been reported as a complication of acute left ventricular (LV) myocardial infarction. It is most commonly observed in cases of LV systolic dysfunction attributed to ischemic or nonischemic etiologies. Conversely, the occurrence of LVT in normal LV systolic function is an exceptionally rare presentation and is predominantly associated with conditions such as hypereosinophilic syndrome (HES), cardiac amyloidosis, left ventricular noncompaction, hypertrophic cardiomyopathy (HCM), hypercoagulability states, immune-mediated disorders, and malignancies. Notably, hypereosinophilia (HE) has been linked with thrombotic events. Intracardiac thrombus is a well-known complication of eosinophilic myocarditis (EM) or Loeffler endomyocarditis, both of which are considered clinical manifestations of HES. We present a case of a 63-year-old male with normal LV systolic function, HE, and noncontributory hypercoagulability workup, who presented with thromboembolic complications arising from LVT. Interestingly, the diagnostic evaluation for EM and Loeffler endocarditis was nonconfirmatory. Additionally, we performed a literature review to delineate all similar cases. This article also outlines the pathophysiology, diagnosis, and treatment approaches for hypereosinophilic cardiac involvement with a specific focus on LVT. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Khachatryan et al.)
Databáze:	MEDLINE
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