A significant outbreak of respiratory human adenovirus infections among children aged 3-6 years in Hokkaido, Japan, in 2023.

Autor: Fukuda Y; Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan., Togashi A; Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan., Hirakawa S; Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan., Yamamoto M; Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan., Fukumura S; Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan., Nawa T; Department of Pediatric Cardiology and Pediatric Intensive Care, Hokkaido Medical Center for Child Health and Rehabilitation, Sapporo, Japan., Kushima N; Department of Pediatrics, Iwamizawa Municipal General Hospital, Hokkaido, Japan., Nakamura S; Department of Pediatrics, Japan Red Cross Urakawa Hospital, Hokkaido, Japan., Kunizaki J; Department of Pediatrics, NTT EC Sapporo Medical Center, Sapporo, Japan., Nishino K; Department of Pediatrics, Otaru Kyokai Hospital, Hokkaido, Japan., Kimura R; Department of Pediatrics, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan., Kizawa T; Department of Pediatrics, Japan Community Health Care Organization Sapporo Hokushin Hospital, Sapporo, Japan., Yamamoto D; Department of Pediatrics, Kushiro City General Hospital, Hokkaido, Japan., Takeuchi R; Department of Pediatrics, Nemuro City Hospital, Hokkaido, Japan., Sasaoka Y; Department of Pediatrics, Hakodate Municipal Hospital, Hokkaido, Japan., Kikuchi M; Department of Pediatrics, Sunagawa City Medical Center, Hokkaido, Japan., Ito T; Department of Pediatrics, Steel Memorial Muroran Hospital, Hokkaido, Japan., Nagai K; Department of Pediatrics, Takikawa Municipal Hospital, Hokkaido, Japan., Asakura H; Department of Pediatrics, Hokkaido Esashi Hospital, Hokkaido, Japan., Nishimura S; Department of Pediatrics, Tomakomai City Hospital, Hokkaido, Japan., Yoshida M; Department of Pediatrics, Yakumo General Hospital, Hokkaido, Japan., Tsuchida K; Department of Pediatrics, Rumoi City Hospital, Hokkaido, Japan., Tsugawa T; Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2024 Jul; Vol. 96 (7), pp. e29780.
DOI: 10.1002/jmv.29780
Abstrakt: Human adenovirus (HAdV) infections present diverse clinical manifestations upon infecting individuals, with respiratory infections predominating in children. We surveyed pediatric hospitalizations due to respiratory HAdV infections across 18 hospitals in Hokkaido Prefecture, Japan, from July 2019 to March 2024, recording 473 admissions. While hospitalizations remained below five cases per week from July 2019 to September 2023, a notable surge occurred in late October 2023, with weekly admissions peaking at 15-20 cases from November to December. There were dramatic shifts in the age distribution of hospitalized patients: during 2019-2021, 1-year-old infants and children aged 3-6 years represented 51.4%-54.8% and 4.1%-13.3%, respectively; however, in 2023-2024, while 1-year-old infants represented 19.0%-20.1%, the proportion of children aged 3-6 years increased to 46.2%-50.0%. Understanding the emergence of significant outbreaks of respiratory HAdV infections and the substantial changes in the age distribution of hospitalized cases necessitates further investigation into the circulating types of HAdV in Hokkaido Prefecture and changes in children's neutralizing antibody titers against HAdV.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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