Epigenetic signals associated with delirium replicated across four independent cohorts.

Autor: Nishizawa Y; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; Department of Psychiatry, Osaka Medical and Pharmaceutical University School of Medicine, Osaka, Japan., Thompson KC; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; University of Nebraska Medical Center, Omaha, NE, USA., Yamanashi T; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Department of Neuropsychiatry, Tottori University Faculty of Medicine, Yonago-shi, Tottori, Japan., Wahba NE; Department of Psychiatry, Oregon Health and Science University, School of Medicine, Portland, OR, USA., Saito T; Department of Psychiatry, National Defense Medical College School of Medicine, Tokorozawa, Saitama, Japan., Marra PS; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Nagao T; Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Department of Neurosurgery (Sakura), Toho University School of Medicine Faculty of Medicine, Sakura-shi, Chiba, Japan., Nishiguchi T; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; Department of Neuropsychiatry, Tottori University Faculty of Medicine, Yonago-shi, Tottori, Japan., Shibata K; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; Sumitomo Pharma Co, Ltd, Osaka, Osaka, Japan., Yamanishi K; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; Department of Neuropsychiatry, Hyogo Medical University, College of Medicine, Nishinomiya, Hyogo, Japan., Hughes CG; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA., Pandharipande P; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA., Cho H; University of Iowa, College of Public Health, Iowa City, IA, USA., Howard MA 3rd; Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Kawasaki H; Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Toda H; Department of Psychiatry, National Defense Medical College School of Medicine, Tokorozawa, Saitama, Japan., Kanazawa T; Department of Psychiatry, Osaka Medical and Pharmaceutical University School of Medicine, Osaka, Japan., Iwata M; Department of Neuropsychiatry, Tottori University Faculty of Medicine, Yonago-shi, Tottori, Japan., Shinozaki G; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA. gens@stanford.edu.; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA. gens@stanford.edu.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 Jul 04; Vol. 14 (1), pp. 275. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1038/s41398-024-02986-w
Abstrakt: Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the epigenetic pathophysiology of delirium remains largely unknown. We aimed to discover reliable and replicable epigenetic (DNA methylation: DNAm) markers that are associated with delirium including post-operative delirium (POD) in blood obtained from patients among four independent cohorts. Blood DNA from four independent cohorts (two inpatient cohorts and two surgery cohorts; 16 to 88 patients each) were analyzed using the Illumina EPIC array platform for genome-wide DNAm analysis. We examined DNAm differences in blood between patients with and without delirium including POD. When we compared top CpG sites previously identified from the initial inpatient cohort with three additional cohorts (one inpatient and two surgery cohorts), 11 of the top 13 CpG sites showed statistically significant differences in DNAm values between the delirium group and non-delirium group in the same directions as found in the initial cohort. This study demonstrated the potential value of epigenetic biomarkers as future diagnostic tools. Furthermore, our findings provide additional evidence of the potential role of epigenetics in the pathophysiology of delirium including POD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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