Reference intervals and percentiles for soluble transferrin receptor and sTfR/log ferritin index in healthy children and adolescents.

Autor:	Prenzel F; Hospital for Children and Adolescents and Center for Pediatric Research (CPL), 70622 Leipzig University , Leipzig, Germany., Kaiser T; Institute for Laboratory Medicine, Microbiology and Pathobiochemistry, University Hospital Ostwestfalen-Lippe (UK-OWL) of Bielefeld University, Detmold, Germany., Willenberg A; 70622 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig , Leipzig, Germany., Vom Hove M; Hospital for Children and Adolescents and Center for Pediatric Research (CPL), 70622 Leipzig University , Leipzig, Germany., Flemming G; Hospital for Children and Adolescents and Center for Pediatric Research (CPL), 70622 Leipzig University , Leipzig, Germany., Fischer L; Hospital for Children and Adolescents and Center for Pediatric Research (CPL), 70622 Leipzig University , Leipzig, Germany., Kratzsch J; 70622 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig , Leipzig, Germany., Kiess W; Hospital for Children and Adolescents and Center for Pediatric Research (CPL), 70622 Leipzig University , Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, 70622 University of Leipzig , Leipzig, Germany., Vogel M; Hospital for Children and Adolescents and Center for Pediatric Research (CPL), 70622 Leipzig University , Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, 70622 University of Leipzig , Leipzig, Germany.
Jazyk:	angličtina
Zdroj:	Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2024 Jul 08; Vol. 63 (1), pp. 184-192. Date of Electronic Publication: 2024 Jul 08 (Print Publication: 2025).
DOI:	10.1515/cclm-2024-0369
Abstrakt:	Objectives: Soluble transferrin receptor (sTfR) is a marker of both erythropoiesis and iron status and is considered useful for detecting iron deficiency, especially in inflammatory conditions, but reference intervals covering the entire pediatric age spectrum are lacking. Methods: We studied 1,064 (48.5 % female) healthy children of the entire pediatric age spectrum to determine reference values and percentiles for sTfR and the ratio of sTfR to log-ferritin (sTfR-F index) using a standard immunoturbidimetric assay. Results: Soluble TfR levels were highly age-specific, with a peak in infancy and a decline in adulthood, whereas the sTfR-F index was a rather constant parameter. There were positive linear relationships for sTfR with hemoglobin (Hb) (p=0.008) and transferrin (females p<0.001; males p=0.003). A negative association was observed between sTfR and ferritin in females (p<0.0001) and for transferrin saturation and mean corpuscular volume (MCV) in both sexes (both p<0.0001). We found a positive relationship between sTfR and body height, body mass index (BMI) and inflammatory markers (CrP p<0.0001; WBC p=0.0172), while sTfR-F index was not affected by inflammation. Conclusions: Soluble TfR values appear to reflect the activity of infant erythropoiesis and to be modulated by inflammation and iron deficiency even in a healthy cohort. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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