The changes and the potential clinical applications of cytokines in Taiwan's major venomous snakebites patients.

Autor: Lin CC; Department of Emergency Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Wang CC; Department of Traumatology and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taiwan., Ou Yang CH; Department of Traumatology and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taiwan., Liu CC; Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan., Yu JS; Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan; Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan; Liver Research Center, Chang Gung Memorial Hospital, Linkou, Tao-Yuan, Taiwan; Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan., Fann WC; Department of Emergency Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan., Chen YC; Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Emergency Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan., Shih CP; Department of Healthcare Management, Yuanpei University of Medical Technology, HsinChu, Taiwan. Electronic address: cpshih@mail.ypu.edu.tw.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Aug 28; Vol. 247, pp. 107843. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1016/j.toxicon.2024.107843
Abstrakt: Background: Taiwan habu (Protobothrops mucrosquamatus), green bamboo viper (Viridovipera stejnegeri), and Taiwan cobra (Naja atra) are the most venomous snakebites in Taiwan. Patients commonly present with limb swelling but misdiagnosis rates are high, and currently available diagnostic tools are limited. This study explores the immune responses in snakebite patients to aid in differential diagnosis.
Methods: This prospective observational study investigated the changes in cytokines in snakebite patients and their potential for diagnosis.
Results: Elevated pro-inflammatory cytokines IL-6 and TNF-α were observed in all snakebite patients compared to the healthy control group. While no significant disparities were observed in humoral immune response cytokines, there were significant differences in IFN-γ levels, with significantly higher IL-10 levels in patients bitten by cobras. Patients with TNF-α levels exceeding 3.02 pg/mL were more likely to have been bitten by a cobra.
Conclusion: This study sheds light on the immune responses triggered by various venomous snakebites, emphasizing the potential of cytokine patterns for snakebite-type differentiation. Larger studies are needed to validate these findings for clinical use, ultimately improving snakebite diagnosis and treatment.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Chih-Chuan Lin reports financial support was provided by the Ministry of Science and Technology of Taiwan (grant MOST 108-2314-B-182A-081). Chun-Hsiang Ou Yang reports financial support was provided by Chang Gung Medcial Foundation, Taoyuan, Taiwan. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The Ministry of Science and Technology of Taiwan and Chang Gang Medical Foundation have no role in this study proposal design, experiment performance, data collection, analysis, and manuscript preparation.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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