Antibiotic resistance trends in high-risk lineages of Salmonella enterica serovar Typhi: A study spanning pre to post COVID-19 pandemic.

Autor: Abro UA; Institute of Microbiology, University of Sindh, Jamshoro, Pakistan., Bano S; Institute of Microbiology, University of Sindh, Jamshoro, Pakistan. Electronic address: shaista.bano@usindh.edu.pk., Tunio SA; Institute of Microbiology, University of Sindh, Jamshoro, Pakistan., Abassi SM; Institute of Microbiology, University of Sindh, Jamshoro, Pakistan; Jinnah Post Graduate Medical Centre, Karachi, Pakistan.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2024 Sep; Vol. 123, pp. 105632. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1016/j.meegid.2024.105632
Abstrakt: Objectives: The aim of this study was to understand the status of extensively drug-resistance (XDR) genotype in Salmonella enterica serotype Typhi (S. Typhi) recovered during the pre to post COVID-19 pandemic period using Multiplex PCR.
Methods: A longitudinal descriptive study was carried out during five years. Antibiotic susceptibility testing was performed according to the Clinical Laboratory Standards Institute antimicrobial susceptibility testing guidelines. The identification of S. Typhi, the detection of their high-risk lineages and XDR genotype was done using single nucleotide polymorphism-based multiplex PCR.
Results: A total of four hundred nine (n = 409) S. Typhi isolates were recovered during pre to post COVID-19 pandemic period. Among them, 30.81% belonged to the pre COVID-19 period while 69.19% to the post COVID-19 period. Different trends in antibiotic resistance in S. Typhi isolates with high prevalence of XDR-S. Typhi were observed. However, there was comparatively different frequency of their occurrence among the S. Typhi isolates recovered during pre to post COVID-19 pandemic period. Multiplex PCR showed that the majority of S. Typhi isolates were the H58 haplotype or genotype 4.3.1 which contained XDR genotype.
Conclusions: The increasing episodes of XDR-S. Typhi causing typhoid fever in endemic areas is alarming. The antibiotic resistance in food and water borne pathogens greatly contribute to the dissemination of the antimicrobial resistance in pathogenic bacteria, which has now been considered as a global concern.
Competing Interests: Declaration of competing interest Authors declare that they have no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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