Age-related differences in retinal function and structure in C57BL/6J and Thy1-YFPh mice.

Autor: Lee PY; Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC, Australia., Bui BV; Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC, Australia. Electronic address: bvb@unimelb.edu.au.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2024 Sep; Vol. 141, pp. 171-181. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1016/j.neurobiolaging.2024.06.005
Abstrakt: Age-related neuronal adaptations are known to help maintain function. This study aims to examine gross age-related in vivo retinal functional adaptations (using electroretinography) in young and middle aged C57BL/6J and Thy1-YFPh mice and to relate this to in vivo retinal structure (using optical coherence tomography). Electroretinography responses were generally larger in Thy1-YFPh mice than in C57BL/6J mice, with similar in vivo retinal layer thicknesses except for longer inner/outer photoreceptor segment in Thy1-YFPh mice. Relative to 3-month-old mice, 12-month-old mice showed reduced photoreceptor (C57BL/6J 84.0±2.5 %; Thy1-YFPh 80.2±5.2 %) and bipolar cell (C57BL/6J 75.6±2.3 %; Thy1-YFPh 68.1±5.5 %) function. There was relative preservation of ganglion cell function (C57BL/6J 79.7±3.7 %; Thy1-YFPh 91.7±5.0 %) with age, which was associated with increased b-wave (bipolar cell) sensitivities to light. Ganglion cell function was correlated with both b-wave amplitude and sensitivity. This study shows that there are normal age-related adaptations to preserve functional output. Different mouse strains may have varied age-related adaptation capacity and should be taken into consideration when examining age-related susceptibility to injury.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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