A prefrontal-habenular circuitry regulates social fear behaviour.

Autor:	Tian Y; Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Nanhu Brain-computer Interface Institute, Hangzhou 311100, China., Zheng J; Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Lingang Laboratory, Shanghai 200031, China., Zhu X; Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310027, China., Liu X; Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Li H; Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Wang J; Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China., Yang Q; Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Zeng LH; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou 310015, China., Shi Z; College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou 310027, China., Gong M; Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310027, China., Hu Y; Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310027, China., Xu H; Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Nanhu Brain-computer Interface Institute, Hangzhou 311100, China.; Lingang Laboratory, Shanghai 200031, China.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2024 Dec 03; Vol. 147 (12), pp. 4185-4199.
DOI:	10.1093/brain/awae209
Abstrakt:	The medial prefrontal cortex (mPFC) has been implicated in the pathophysiology of social impairments, including social fear. However, the precise subcortical partners that mediate mPFC dysfunction on social fear behaviour have not been identified. Using a social fear conditioning paradigm, we induced robust social fear in mice and found that the lateral habenula (LHb) neurons and LHb-projecting mPFC neurons are activated synchronously during social fear expression. Moreover, optogenetic inhibition of the mPFC-LHb projection significantly reduced social fear responses. Importantly, consistent with animal studies, we observed an elevated prefrontal-habenular functional connectivity in subclinical individuals with higher social anxiety characterized by heightened social fear. These results unravel a crucial role of the prefrontal-habenular circuitry in social fear regulation and suggest that this pathway could serve as a potential target for the treatment of social fear symptoms often observed in many psychiatric disorders. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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