Unlocking the therapeutic potential: odyssey of induced pluripotent stem cells (iPSC) in precision cell therapies.

Autor: Mohite P; AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra-401404, India., Dave R; AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra-401404, India., Budhar A; AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra-401404, India., Munde S; AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra-401404, India., Puri A; AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra-401404, India., Ghosh SB; Department of Pharmaceutical Chemistry, Calcutta Institute of Pharmaceutical Technology and Allied Health Science, Uluberia, Howrah, 711316, India., Alqahtani T; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia., Shmrany HA; Department of Medical Laboratory Sciences, College of Applied medical sciences, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia., Kumer A; Department of Chemistry, IUBAT-International University of Business Agriculture & Technology, Dhaka, Bangladesh., Dhara B; Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India.; Department of Health Sciences, Novel Global Community and Educational Foundation. Hebersham, Australia.
Jazyk: angličtina
Zdroj: International journal of surgery (London, England) [Int J Surg] 2024 Jul 04. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1097/JS9.0000000000001892
Abstrakt: This review explores the application of induced pluripotent stem cells (iPSCs) in regenerative medicine. The therapeutic significance of iPSC-derived cell therapy within regenerative medicine, emphasizes their reprogramming process and crucial role in cellular differentiation while setting the purpose and scope for the comprehensive exploration of iPSC-derived cell therapy. The subsequent sections intricately examine iPSC-derived cell therapy, unravelling the diverse derivatives of iPSCs and striking a delicate balance between advantages and limitations in therapeutic applications. Mechanisms of action, revealing how iPSC-derived cells seamlessly integrate into tissues, induce regeneration, and contribute to disease modeling and drug screening advancements is discussed. The analysis extends to clinical trials, shedding light on outcomes, safety considerations, and ethical dimensions. Challenges and concerns, including the risk of tumorigenesis and scalability issues, are explored. The focus extends to disease-specific applications, showcasing iPSC-derived cell therapy as a promising avenue for various medical conditions, supported by illustrative case studies. Future directions and research needs are outlined, identifying areas for further exploration, safety considerations and potential enhancements that will shape the future landscape of iPSC-derived therapies. In conclusion, this review provides significant understanding of iPSC-derived cell therapy's status, that contemplates the implications for regenerative medicine and personalized treatment using iPSCs, offering a comprehensive perspective on the evolving field within the confines of a dynamic and promising scientific frontier.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze: MEDLINE
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