Comparative study of Lepidium sativum orally administered seeds, hydrogel and atorvastatin on obesity of rats fed on a high fat diet.

Autor:	Aldosari BN; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Tawfeek HM; Industrial Pharmacy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Abdellatif AAH; Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt., Almurshedi AS; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Alfagih IM; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., AlQuadeib BT; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Abbas AYA; Histology and Cell Biology Department, Faculty of Medicine, Assiut University, Assiut, Egypt., Mohammed HM; Puplic Health and Community Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt., Hassan YA; Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Al-Kitab University, Kirkuk, Iraq.; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt., Fayed MH; Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia.; Department of Pharmaceutics, Faculty of Pharmacy, Fayoum University, Faiyum, Egypt., Tolba NS; Department of Pharmaceutics, Faculty of Pharmacy, Sadat City University, Sadat City, Egypt.
Jazyk:	angličtina
Zdroj:	Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2024 Jul; Vol. 50 (7), pp. 605-618. Date of Electronic Publication: 2024 Jul 11.
DOI:	10.1080/03639045.2024.2376624
Abstrakt:	Background: Obesity has become a prevalent issue worldwide, leading to various complications such as hyperlipidemia, diabetes, and cardiovascular problems. Statins, as FDA approved anti-hyperlipidemic drugs, still pose some concerns upon their administration. Recently, researchers have looked for natural products as an alternative to manage hyperlipidemia and obesity. Aim: This work aimed to study the hypolipidemic effect of Lepidium sativum garden cress (GC) from different preparations; orally administered seeds, and hydrogel, in comparison to atorvastatin. Methods: GC hydrogel was prepared from the GC aqueous extract and pharmaceutically evaluated for its pH, spreadability, seeds content, homogeneity, rheology, and in vitro release. The rat's body weight, blood glucose levels, total lipid profile, and liver biomarkers were evaluated on obese rats for one month. In addition, the histopathology study was also performed. Results: GC hydrogel had acceptable pharmaceutical properties and showed a sustained release performance over 24 h. Oral and topical GC significantly reduced the lipid profiles, blood sugar and ALT, AST levels more than the negative control group and comparable to atorvastatin. It was found that oral GC showed a significant effect on the percentage decrease in the rat's body weight than the applied hydrogel. Histopathology study revealed a better outcome in the histological structure of pancreas and liver compared with rats feed on high fat diet post-treatment for one month. Conclusion: GC orally administered, or topically applied hydrogel could be a promising, safe alternative formulation to atorvastatin in managing hyperlipidemia and normalizing body weight of obese rats.
Databáze:	MEDLINE
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