Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients.

Autor: Brier MR; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Schindler SE; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Salter A; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Perantie D; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Shelley N; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Judge B; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Keefe S; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Kirmess KM; C2N Diagnostics, St. Louis, MO, USA., Verghese PB; C2N Diagnostics, St. Louis, MO, USA., Yarasheski KE; C2N Diagnostics, St. Louis, MO, USA., Venkatesh V; C2N Diagnostics, St. Louis, MO, USA., Raji CA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Gordon BA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Bateman RJ; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Morris JC; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Naismith RT; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Benzinger TLS; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Cross AH; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Jazyk: angličtina
Zdroj: Annals of neurology [Ann Neurol] 2024 Sep; Vol. 96 (3), pp. 453-459. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1002/ana.27027
Abstrakt: The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid-β plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024;96:453-459.
(© 2024 American Neurological Association.)
Databáze: MEDLINE
Externí odkaz: