Cyclodextrins as a Strategy for Enhancing Solubility of Therapeutic Agents for Neglected Tropical Diseases: A Systematic Review.

Autor:	Melo DF; Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco. Av. Prof. Artur de Sá - Cidade Universitária, Recife, Pernambuco, Brazil., Alves LP; Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco. Av. Prof. Artur de Sá - Cidade Universitária, Recife, Pernambuco, Brazil., Silva NM; Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco. Av. Prof. Artur de Sá - Cidade Universitária, Recife, Pernambuco, Brazil., Silva LCPBB; Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco. Av. Prof. Artur de Sá - Cidade Universitária, Recife, Pernambuco, Brazil., Holanda BFLA; Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco. Av. Prof. Artur de Sá - Cidade Universitária, Recife, Pernambuco, Brazil., Souza ML; Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco. Av. Prof. Artur de Sá - Cidade Universitária, Recife, Pernambuco, Brazil., Rolim LA; Drug, Medicine and Food Analytical Center; College of Pharmaceutical Sciences, Federal University of Vale do São Francisco. Av. José de Sá Maniçoba, Petrolina, Pernambuco., Neto PJR; Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco. Av. Prof. Artur de Sá - Cidade Universitária, Recife, Pernambuco, Brazil.
Jazyk:	angličtina
Zdroj:	Current medicinal chemistry [Curr Med Chem] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03.
DOI:	10.2174/0109298673318410240627031819
Abstrakt:	Background: Neglected Tropical Diseases (NTD) are chronic infectious conditions that primarily affect marginalized populations. The chemotherapeutic arsenal available for treating NTD is limited and outdated, which poses a challenge in controlling and eradicating these diseases. This is exacerbated by the pharmaceutical industry's lack of interest in funding the development of new therapeutic alternatives. In addition, a considerable number of drugs used in NTD therapy have low aqueous solubility. To address this issue, solubility enhancement strategies, such as the use of inclusion complexes with cyclodextrins (CD) can be employed. Objective: Therefore, this systematic review aims to present the application of CD in complexing with drugs and chemotherapeutic compounds used in the therapy of some of the most prevalent NTD worldwide and how these complexes can enhance the treatment of these diseases. Methods: Two bibliographic databases, Science Direct and PubMed, were used to conduct the search. The selection of studies and the writing of this systematic review followed the criteria outlined by the PRISMA guidelines. Results: From a total of 978 articles, 23 were selected after applying the exclusion criteria. All the studies selected were consistent with the use of CD as a strategy to increase the solubility of therapeutic agents used in NTD. Conclusion: The results indicate that CD can enhance the solubility of chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTD). This review presents data that clearly highlights the potential use of CD in the development of new treatments for neglected tropical diseases. It can assist in the formulation of future treatments that are more effective and safer. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu