Tenofovir-Associated Kidney Dysfunction and Bone Fracture: A Case Report and Literature Review.

Autor:	Athish KK; Department of Internal Medicine, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND., Nayak Rao S; Department of Nephrology, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND., Marimuthu VH; Department of Emergency Medicine, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND., Krishna V; Department of Internal Medicine, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND., Arun A; Department of Internal Medicine, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 03; Vol. 16 (6), pp. e61562. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024).
DOI:	10.7759/cureus.61562
Abstrakt:	Tenofovir is an integral part of antiretroviral therapy used to treat HIV. Long-term use of tenofovir has been associated with decreased glomerular filtration rate, leading to chronic kidney disease, as well as acidosis, electrolyte imbalances, and tubular dysfunction. Tenofovir can also disrupt bone health by decreasing renal phosphate absorption, contributing to osteomalacia. This leads to disruption in mineral metabolism, elevated parathyroid hormone levels, and ultimately, low bone mineral density. Replacing tenofovir with alternative antiretroviral therapy can improve kidney function if done early in the course of the disease. Here, we discuss a case of a 65-year-old woman with HIV who presented with advanced renal failure and hypophosphatemia-induced bone fracture attributed to long-term use of tenofovir. We conclude monitoring kidney function and considering alternative antiretroviral therapy is important to prevent and manage these side effects in patients on long-term tenofovir therapy. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Athish et al.)
Databáze:	MEDLINE
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