The Effect of Targeted Temperature Therapy on Antioxidant Levels in Patients With Spontaneous Circulation After Cardiac Arrest.

Autor:	Yazar V; Anesthesiology and Reanimation, Mehmet Akif Inan Training and Research Hospital, Şanlıurfa, TUR., Binici O; Anesthesiology and Critical Care, Harran University, Şanlıurfa, TUR., Karahan MA; Anesthesiology and Reanimation, Mehmet Akif Inan Training and Research Hospital, Şanlıurfa, TUR., Bilsel MB; Anesthesiology and Reanimation, Mehmet Akif Inan Training and Research Hospital, Şanlıurfa, TUR., Pehlivan VF; Anesthesiology, Harran University, Şanlıurfa, TUR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 03; Vol. 16 (6), pp. e61578. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024).
DOI:	10.7759/cureus.61578
Abstrakt:	Introduction In this study, we aimed to measure the change in total antioxidant status (TAS), total oxidant stress (TOS), oxidative stress index (OSI), and nuclear factor erythroid 2 (Nrf-2) levels during the treatment period in patients who restored spontaneous circulation return after cardiac arrest with targeted temperature management (TTM) therapy in our hospital. Methods The study included 36 patients who were hospitalized in the anesthesia intensive care unit and coronary intensive care unit of our hospital and were treated with TTM therapy after cardiac arrest. TAS, TOS, OSI, and Nrf-2 levels were measured at 0 (beginning), 12, 24, and 48 (end) hours of TTM therapy. Results The mean age of the patients participating in the study was 54.25±17.10. TAS and TOS levels decreased gradually during TTM therapy, but statistically significant decrease was observed at the end of the hour. When Nrf-2 and OSI levels were evaluated, it was found that no statistically significant difference was observed during the TTM therapy. Conclusion In our study, the oxidant-antioxidant balance was preserved in patients who received TTM therapy after cardiac arrest. We predict TTM therapy is effective on oxidative stress after cardiac arrest and should be applied for at least 48 hours. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Harran University Faculty of Medicine's Ethics Committee issued approval 2020.08/24. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Yazar et al.)
Databáze:	MEDLINE
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