A Systematic Review and Meta-Analysis on the Role of Bempedoic Acid in Cardiovascular Outcomes for Patients With Statin Intolerance.
| Autor: | Serour MH; Cardiology, Sheikh Khalifa Specialty Hospital, Ras al Khaimah, ARE., Egaimi M; Medicine, Royal College of Physicians of Edinburgh, Edinburgh, GBR.; Cardiology, Sheikh Khalifa Specialty Hospital, Ras al Khaimah, ARE., Khan Z; Acute Medicine, Mid and South Essex NHS Foundation Trust, Southend on Sea, GBR.; Cardiology, Barts Heart Centre, London, GBR.; Cardiology and General Medicine, Barking, Havering and Redbridge University Hospitals NHS Trust, London, GBR.; Cardiology, Royal Free Hospital, London, GBR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jun 03; Vol. 16 (6), pp. e61572. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.61572 |
| Abstrakt: | Atherosclerosis, a multifaceted pathogenic process affecting the arteries and aorta, poses a significant threat because of its potential to impede or entirely obstruct blood flow by narrowing blood vessels. This intricate progression involves various factors such as dyslipidemia, immunological responses, inflammation, and endothelial dysfunction. The initial phase manifests as the formation of fatty streaks, considered a pivotal hallmark in the inception of atherosclerotic plaques, a process that can commence as early as childhood. Over time, this process evolves, characterized by the thickening of the arterial inner layer (intima) and accumulation of lipid-laden macrophages, commonly known as foam cells, along with the buildup of the extracellular matrix. Subsequent stages witness the proliferation and aggregation of smooth muscle cells, culminating in the formation of atheroma plaques. As these lesions progress, apoptosis can occur in the deeper layers, further recruiting macrophages, which may undergo calcification and transform into atherosclerotic plaques. Notably, mechanisms such as arterial remodeling and intraplaque hemorrhage also contribute significantly to the progression of atherosclerotic cardiovascular disease, although these facets fall beyond the scope of this article. This study aimed to systematically review and conduct a meta-analysis of randomized controlled trials investigating the efficacy and safety of bempedoic acid in statin-intolerant patients with hyperlipidemia and to provide conclusions and recommendations accordingly. A systematic search of databases, such as PubMed, Web of Science, and Embase, will be performed. Only randomized trials will be included comparing bempedoic acid with placebo in statin-intolerant patients. This study aimed to provide a comprehensive understanding of the role of bempedoic acid in managing hyperlipidemia in statin-intolerant patients. In primary prevention, for patients unable to tolerate recommended statins, bempedoic acid was associated with a significant reduction in major adverse cardiovascular events (MACE) as the primary endpoint. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Serour et al.) |
| Databáze: | MEDLINE |
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