Laryngeal Preservation Rate and Salvage Therapy Following Initial Recurrence in a Real-world Setting After Definitive Radiation Therapy in Patients With Locally Advanced Laryngeal Squamous Cell Carcinoma.

Autor:	Katano A; Department of Radiology, The University of Tokyo Hospital, Tokyo, Japan., Maemura T; Department of Radiology, The University of Tokyo Hospital, Tokyo, Japan., Minamitani M; Department of Comprehensive radiation oncology, The University of Tokyo, Tokyo, Japan., Ohira S; Department of Comprehensive radiation oncology, The University of Tokyo, Tokyo, Japan., Yamashita H; Department of Radiology, The University of Tokyo Hospital, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	Cancer diagnosis & prognosis [Cancer Diagn Progn] 2024 Jul 03; Vol. 4 (4), pp. 424-429. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024).
DOI:	10.21873/cdp.10342
Abstrakt:	Background/aim: The larynx plays a pivotal role in vocalization and airway protection, and laryngeal cancer manifests through various symptoms. Contemporary strategies focus on laryngeal preservation, particularly through non-surgical modality therapies that utilize radiotherapy. The aim of this study was to assess the laryngeal preservation rate after definitive radiation therapy in patients with locally advanced laryngeal squamous cell carcinoma and investigate salvage therapy subsequent to the initial recurrence in a real-world context. Patients and Methods: Analysis included a total of 40 patients with locally advanced laryngeal squamous cell carcinoma who were treated with definitive radiotherapy in the University of Tokyo Hospital. Treatment involved external beam radiotherapy (70 Gy in 35 fractions) with elective nodal irradiation. The main study outcomes were assessment of survival, overall survival, local control, and the factors influencing laryngeal preservation. Results: The patients exhibited a median age of 64.5 years, and 80% of them were men. Chemotherapy was administered to 82.5% of the patients. The 3-year overall survival, progression-free, and laryngeal preservation survival rates were 86.3%, 66.8%, and 78.4%, respectively. Univariate and multivariate analyses identified chemotherapy to be significantly associated with favorable laryngeal preservation survival (p<0.001). Conclusion: Definitive radiotherapy results in favorable outcomes for laryngeal preservation in locally advanced laryngeal squamous cell carcinoma. This study emphasizes the importance of chemotherapy in comprehensive patient management. Nevertheless, larger prospective studies are crucial to validate and optimize therapeutic approaches for this condition. Competing Interests: MM and SO are affiliated with the Department of Comprehensive Radiation Oncology, which is an endowed department funded by an unrestricted grant from Elekta K.K. and Chiyoda Technol Corporation. However, it is important to note that no funding was received from them specifically to conduct this study. (Copyright 2024, International Institute of Anticancer Research.)
Databáze:	MEDLINE
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