Effect of occupational exposure to vat-textile dyes on follicular and luteal hormones in female dye workers in Abeokuta, Nigeria.

Autor:	Soyinka OO; Department of Chemical Pathology and Immunology, College of Health Sciences, Sagamu Campus, Olabisi Onabanjo University, Ago Iwoye, Nigeria., Akinsanya AF; Department of Obstetrics and Gynaecology, College of Health Sciences, Sagamu Campus, Olabisi Onabanjo University, Ago Iwoye, Nigeria., Odeyemi FA; Department of Chemical Pathology and Immunology, College of Health Sciences, Sagamu Campus, Olabisi Onabanjo University, Ago Iwoye, Nigeria., Amballi AA; Department of Chemical Pathology and Immunology, College of Health Sciences, Sagamu Campus, Olabisi Onabanjo University, Ago Iwoye, Nigeria., Oritogun KS; Department of Community Medicine, College of Health Sciences, Sagamu Campus, Olabisi Onabanjo University, Ago Iwoye, Nigeria., Ogundahunsi OA; Department of Chemical Pathology and Immunology, College of Health Sciences, Sagamu Campus, Olabisi Onabanjo University, Ago Iwoye, Nigeria.
Jazyk:	angličtina
Zdroj:	African health sciences [Afr Health Sci] 2024 Mar; Vol. 24 (1), pp. 135-144.
DOI:	10.4314/ahs.v24i1.17
Abstrakt:	Background: Some synthetic dyes used mainly in textile industries have been associated with endocrine disruption, resulting in infertility, among other disorders. It is unknown if occupational exposure to Vat textile dyes among premenopausal dyers alters hormonal levels. Objectives: We aimed at determining the probable effects of occupational exposure to Vat dyes on reproductive hormones of female textile dyers in the follicular and luteal phases while relating this to age categories and duration of exposure. Methods: Thirty-three premenopausal Vat textile dyers at "Itoku", Abeokuta, Nigeria, among a population of about 80 female dyers were age and sex-matched with 55 non-exposed (control) female participants. Using semi-structured questionnaires, socio-demographic, occupational details and the LMP of participants were obtained. Serum samples were collected in follicular and luteal phases and assayed for female sex hormones using Enzyme Immunoassay. Mann-Whitney U and Z- statistic were used for comparison of the two groups. P-value < 0.05 was considered to be significant. Results: In the follicular phase, the result showed a lower mean FSH ranking (in age category ≤20 years) and higher (p<0.05) Estradiol ranking (in age category 31-40 years) in the exposed than the unexposed. Mean ranks of Progesterone and Estradiol in the luteal phase (age category 31-40 years) were higher (p<0.05) in the exposed, while Estradiol (age category ≥41years) ranked lower (p<0.05). Prolactin demonstrated a significant inverse relationship with the duration of exposure. Conclusion: Occupational exposure to Vat dye among female dyers in Abeokuta is associated with some sex hormone disruption which appears to be age and duration of exposure-related. Competing Interests: The authors have no competing interests to declare that are relevant to the content of this article. (© 2024 Soyinka OO et al.)
Databáze:	MEDLINE
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