The utilization of chitosan/ Bletilla striata hydrogels to elevate anti-adhesion, anti-inflammatory and pro-angiogenesis properties of polypropylene mesh in abdominal wall repair.

Autor:	Di Y; Department of Neurosurgery, The Fourth Central Hospital of Baoding City, Baoding 072350, China., Wang L; Research Center for Biomedical Engineering, Medical Innovation & Research Division, Chinese PLA General Hospital, Key Laboratory of Biomedical Engineering and Translational Medicine, Ministry of Industry and Information Technology, Beijing 100853, China., He W; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China., Liu S; College of Lab Medicine, Hebei North University, Zhangjiakou 075000, China., He Y; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China., Liao J; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China., Zhang R; Department of Neurosurgery, The Fourth Central Hospital of Baoding City, Baoding 072350, China., Yin L; Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University, Beijing 100084, China., Xu Z; College of Lab Medicine, Hebei North University, Zhangjiakou 075000, China., Li X; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
Jazyk:	angličtina
Zdroj:	Regenerative biomaterials [Regen Biomater] 2024 Apr 27; Vol. 11, pp. rbae044. Date of Electronic Publication: 2024 Apr 27 (Print Publication: 2024).
DOI:	10.1093/rb/rbae044
Abstrakt:	Polypropylene (PP) mesh is commonly used in abdominal wall repair due to its ability to reduce the risk of organ damage, infections and other complications. However, the PP mesh often leads to adhesion formation and does not promote functional tissue repair. In this study, we synthesized one kind of aldehyde Bletilla striata polysaccharide (BSPA) modified chitosan (CS) hydrogel based on Schiff base reaction. The hydrogel exhibited a porous network structure, a highly hydrophilic surface and good biocompatibility. We wrapped the PP mesh inside the hydrogel and evaluated the performance of the resulting composites in a bilateral 1 × 1.5 cm abdominal wall defect model in rats. The results of gross observation, histological staining and immunohistochemical staining demonstrated the positive impact of the CS hydrogel on anti-adhesion and wound healing effects. Notably, the addition of BSPA to the CS hydrogel further improved the performance of the composites in vivo , promoting wound healing by enhancing collagen deposition and capillary rearrangement. This study suggested that the BSPA-modified CS hydrogel significantly promoted the anti-adhesion, anti-inflammatory and pro-angiogenesis properties of PP meshes during the healing process. Overall, this work offers a novel approach to the design of abdominal wall repair patches. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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