Episodes of acute methotrexate-related neurotoxicity linked to compromised long-term neurocognitive function.

Autor: Harris RD; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA., Taylor OA; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA., Raghubar KP; Department of Pediatrics, Division of Psychology, Baylor College of Medicine, Houston, Texas, USA.; Department of Pediatric Psychology and Neuropsychology, Texas Children's Hospital, Houston, Texas, USA., Matheus Gonzalez M; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA., Zobeck M; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA., Gramatges MM; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA., Rabin KR; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA., Scheurer ME; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA., Brown AL; Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Sep; Vol. 71 (9), pp. e31169. Date of Electronic Publication: 2024 Jul 03.
DOI: 10.1002/pbc.31169
Abstrakt: Methotrexate is a critical component of curative chemotherapy for pediatric acute lymphoblastic leukemia (ALL), but is associated with neurotoxicity. Information on long-term outcomes following an acute neurotoxic event is limited. Therefore, this report compares neurocognitive performance more than 12 months post diagnosis (mean = 4 years) between ALL patients with (n = 25) and without (n = 146) a history of acute neurotoxicity. Compared to children with no documented on-treatment neurotoxic event, children who experienced a neurotoxic event during treatment exhibited poorer performance on measures of fine motor function (p = .02) and attention (p = .02). Children with ALL who experience acute neurotoxicity may be candidates for early neuropsychological screening and intervention.
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Databáze: MEDLINE
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