Pilot Experiment on Non-Invasive Non-Thermal Disintegration of Human Mucinous Breast Carcinoma Ex Vivo Using Boiling Histotripsy.

Autor: Ponomarchuk EM; Lomonosov Moscow State University, Moscow, Russia. ponomarchuk.em14@physics.msu.ru., Tsysar SA; Lomonosov Moscow State University, Moscow, Russia., Chupova DD; Lomonosov Moscow State University, Moscow, Russia., Pestova PA; Lomonosov Moscow State University, Moscow, Russia., Kvashennikova AV; Lomonosov Moscow State University, Moscow, Russia., Danilova NV; Lomonosov Moscow State University, Moscow, Russia., Malkov PG; Lomonosov Moscow State University, Moscow, Russia., Chernyaev AL; Research Institute of Pulmonology, Federal Medical-Biological Agency of Russia, Moscow, Russia.; Avtsyn Research Institute of Human Morphology, Petrovsky Russian Research Center of Surgery, Moscow, Russia., Buravkov SV; Lomonosov Moscow State University, Moscow, Russia., Khokhlova VA; Lomonosov Moscow State University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 May; Vol. 177 (1), pp. 133-136. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1007/s10517-024-06144-6
Abstrakt: We present the results of a pilot study demonstrating the feasibility of non-invasive non-thermal disintegration of human mucinous carcinoma of the breast ex vivo using sequences of high-intensity focused ultrasound pulses in boiling histotripsy regimen. The target volume was sonicated by focusing ultrasound pulses (n=20) of 1.5 MHz frequency, 10-msec duration and 1-sec pulse repetition period, 517 W acoustic power within the pulse, and 103 MPa shock front amplitude at the focus into each node of a volumetric grid 4×4×1 mm. Sonication was visualized and controlled using B-mode ultrasound imaging, total time of the treatment was 21 min. Histological hematoxylin and eosin and Masson's trichrome staining revealed the absence of tumor elements in the treated region confirming destruction of cancer cells and their nuclei after boiling histotripsy procedure.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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