Potential biomarkers of ASD a target for future treatments: oxidative stress, chemokines, apoptotic, and methylation capacity.

Autor:	Zaki M; Biological Anthropology Department, 68787 Medical Research and Clinical Studies Institute-National Research Centre , Cairo, Egypt., Youness ER; Medical Biochemistry Department, 68787 Medical Research and Clinical Studies Institute-National Research Centre , Cairo, Egypt., Orban HA; Medical Biochemistry Department, 68787 Medical Research and Clinical Studies Institute-National Research Centre , Cairo, Egypt., Ahmed HM; Medical Biochemistry Department, 68787 Medical Research and Clinical Studies Institute-National Research Centre , Cairo, Egypt., Moustafa RSI; Child Health Department, 68787 Medical Research and Clinical Studies Institute, National Research Centre , Cairo, Egypt., Alzaree FA; Child Health Department, 68787 Medical Research and Clinical Studies Institute, National Research Centre , Cairo, Egypt., Ashaat EA; Clinical Genetics Department, 68787 Human Genetics and Genome Research Institute, National Research Centre , Cairo, Egypt., El-Bassyouni HT; Clinical Genetics Department, 68787 Human Genetics and Genome Research Institute, National Research Centre , Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Journal of complementary & integrative medicine [J Complement Integr Med] 2024 Jul 04. Date of Electronic Publication: 2024 Jul 04.
DOI:	10.1515/jcim-2024-0145
Abstrakt:	Objectives: The study aimed to assess the effect of these biomarkers on a sample of children with autism spectrum disorder (ASD) to help in early diagnosis and intervention. Methods: A total of 71 autistic patients and 65 normal controls were enrolled in this study. Their ages ranged from 5 to 11 years (mean ± SD 7.47 ± 3.81). Childhood Autism Rating Scale (CARS) was assessed for all patients and controls. Assessment of oxidative stress, monocyte chemoattractant protein-1, B-cell lymphoma 2, S-adenosylhomocysteine (SAH), and apelin was performed. Results: Oxidative stress (oxidized low-density lipoprotein and malonaldehyde) increased while antioxidant paraoxonase (PON) decreased. Monocyte chemoattractant protein-1, B-cell lymphoma 2, and S-adenosylhomocysteine (SAH) were all elevated whereas, apelin was downregulated. Conclusions: It is important to note that many factors that may contribute to ASD including genetic factors. To open the door for novel treatment strategies, it is still necessary to precisely understand how oxidative stress, chemokines, apoptosis, and methylation capability affect the metabolism of people with ASD. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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