Exploring metalloproteins found in the secretion of venomous species: Biological role and therapeutical applications.

Autor:	Lopes Júnior CA; Grupo de Estudo em Bioanalítica (GEBIO), Department of Chemistry, Federal University of Piauí-UFPI, Teresina, Piauí, Brazil. Electronic address: ciceroalj@ufpi.edu.br., Mendes MKA; Grupo de Estudo em Bioanalítica (GEBIO), Department of Chemistry, Federal University of Piauí-UFPI, Teresina, Piauí, Brazil., Sousa MDS; Grupo de Estudo em Bioanalítica (GEBIO), Department of Chemistry, Federal University of Piauí-UFPI, Teresina, Piauí, Brazil., Vieira EC; Grupo de Estudo em Bioanalítica (GEBIO), Department of Chemistry, Federal University of Piauí-UFPI, Teresina, Piauí, Brazil., Andrade TA; Faculty of Chemistry, Federal University of Sul e Sudoeste do Pará, Marabá, Pará, Brazil., de Jesus JR; Research Laboratory in Bionanomaterials, LPbio, Department of Chemistry, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Jazyk:	angličtina
Zdroj:	Advances in protein chemistry and structural biology [Adv Protein Chem Struct Biol] 2024; Vol. 141, pp. 539-562. Date of Electronic Publication: 2024 Jun 12.
DOI:	10.1016/bs.apcsb.2024.03.002
Abstrakt:	Several species during evolution suffered random mutations in response to various environmental factors, which resulted in the formation of venom in phylogenetically distant species. The composition of the venom of most species is poorly known. Snake venom is well characterized while most species have poorly known composition. In contrast, snake venoms are well characterized which proteins and peptides are the main active and most abundant constituents. 42 protein families have been identified, including metalloproteins known as metalloproteinases. These macromolecules are enzymes with zinc in their active site derived from the disintegrin A and metalloproteinase (ADAM) cellular family and are categorized into three classes (PI, PII and PIII) according to their domain organization. The snake venom metalloproteinases (SVMP) are cytotoxic, neurotoxic, myotoxic and/or hematotoxic with a crucial role in the defense and restraint of prey. In this scenario envenoming represents a danger to human health and has been considered a neglected disease worldwide, particularly in tropical and subtropical countries. Nevertheless, recently advances in "omics" technologies have demonstrated interesting biological activities of SVMPs such as antimicrobial, anticancer, against cardiovascular diseases and nervous system disorders. Metalloproteins have the therapeutic potential to be converted into drugs as other components of the venom have undergone this process (e.g., captopril, tirefiban and eptifibatide). So, this chapter is focused on the metalloproteins found in the secretions of venomous species, highlight some aspects such as structure, biological activity, pharmacological therapeutic potential and on. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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