Association of maternal fish consumption and ω-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis.
Autor: | Lyall K; AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, United States. Electronic address: kld98@drexel.edu., Westlake M; RTI International, Raleigh, NC, United States., Musci RJ; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Gachigi K; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Barrett ES; Department of Biostatistics and Epidemiology, Rutgers University School of Public Health, Environmental and Occupational Health Sciences Institute, Piscataway, NJ, United States., Bastain TM; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, United States., Bush NR; Department of Psychiatry and Behavioral Sciences, Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States., Buss C; UC Irvine Medical Center, Orange, CA, United States., Camargo CA Jr; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Croen LA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States., Dabelea D; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Dunlop AL; Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, United States., Elliott AJ; Avera Research Institute, Sioux Falls, SD, United States; Department of Pediatrics, University of South Dakota Sanford School of Medicine, Vermillion, SD, United States., Ferrara A; Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States., Ghassabian A; Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States., Gern JE; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States., Hare ME; Department of Preventive Medicine, College of Medicine, University of Health Science Center, Memphis, TN, United States., Hertz-Picciotto I; Department of Public Health Sciences, University of California Davis, Davis, CA, United States., Hipwell AE; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Hockett CW; Avera Research Institute, Sioux Falls, SD, United States; Department of Pediatrics, University of South Dakota Sanford School of Medicine, Vermillion, SD, United States., Karagas MR; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States., Lugo-Candelas C; New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, United States., O'Connor TG; Departments of Psychiatry, Psychology, Neuroscience, Obstetrics and Gynecology, University of Rochester, Rochester, NY, United States., Schmidt RJ; Department of Public Health Sciences, University of California Davis, Davis, CA, United States., Stanford JB; Department of Family and Preventative Medicine, University of Utah, Salt Lake City, UT, United States., Straughen JK; Department of Public Health Sciences, Henry Ford Health, Detroit, MI, United States., Shuster CL; Brown Center for the Study of Children at Risk, Women and Infants Hospital, Providence, RI, United States., Wright RO; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Wright RJ; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Zhao Q; Department of Preventive Medicine, College of Medicine, University of Health Science Center, Memphis, TN, United States., Oken E; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States. |
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Jazyk: | angličtina |
Zdroj: | The American journal of clinical nutrition [Am J Clin Nutr] 2024 Sep; Vol. 120 (3), pp. 583-592. Date of Electronic Publication: 2024 Jul 01. |
DOI: | 10.1016/j.ajcnut.2024.06.013 |
Abstrakt: | Background: Prenatal fish intake is a key source of omega-3 (ω-3) polyunsaturated fatty acids needed for brain development, yet intake is generally low, and studies addressing associations with autism spectrum disorder (ASD) and related traits are lacking. Objective: This study aimed to examine associations of prenatal fish intake and ω-3 supplement use with both autism diagnosis and broader autism-related traits. Methods: Participants were drawn from 32 cohorts in the Environmental influences on Child Health Outcomes Cohort Consortium. Children were born between 1999 and 2019 and part of ongoing follow-up with data available for analysis by August 2022. Exposures included self-reported maternal fish intake and ω-3/fish oil supplement use during pregnancy. Outcome measures included parent report of clinician-diagnosed ASD and parent-reported autism-related traits measured by the Social Responsiveness Scale (SRS)-second edition (n = 3939 and v3609 for fish intake analyses, respectively; n = 4537 and n = 3925 for supplement intake analyses, respectively). Results: In adjusted regression models, relative to no fish intake, fish intake during pregnancy was associated with reduced odds of autism diagnosis (odds ratio: 0.84; 95% confidence interval [CI]: 0.77, 0.92), and a modest reduction in raw total SRS scores (β: -1.69; 95% CI: -3.3, -0.08). Estimates were similar across categories of fish consumption from "any" or "less than once per week" to "more than twice per week." For ω-3 supplement use, relative to no use, no significant associations with autism diagnosis were identified, whereas a modest relation with SRS score was suggested (β: 1.98; 95% CI: 0.33, 3.64). Conclusions: These results extend previous work by suggesting that prenatal fish intake, but not ω-3 supplement use, may be associated with lower likelihood of both autism diagnosis and related traits. Given the low-fish intake in the United States general population and the rising autism prevalence, these findings suggest the need for better public health messaging regarding guidelines on fish intake for pregnant individuals. Competing Interests: Conflicts of interest The authors report no conflicts of interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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