Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification.

Autor:	Shen H; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China., Zhou L; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China., Zhang H; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China., Yang Y; Department of Blood Transfusion, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Jiang L; Department of Nephropathy, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China., Wu D; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China., Shu H; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China., Zhang H; Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China., Xie L; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China., Zhou K; Institute for Immunology, School of Basic Medical Science, Tsinghua University, Beijing 100084, China., Cheng C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China., Yang L; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China., Jiang J; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China., Wang S; Department of Geriatrics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230002, China; Anhui Key Laboratory of Geriatric Immunology and Nutrition Therapy, Hefei 230027, China., Han Y; Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei 230032, China., Zhu J; Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei 230032, China., Xu L; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China., Liu Z; Institute for Immunology, School of Basic Medical Science, Tsinghua University, Beijing 100084, China. Electronic address: zhihualiu@mail.tsinghua.edu.cn., Wang H; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China. Electronic address: wanghua@ahmu.edu., Yin S; Department of Geriatrics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230002, China; Anhui Key Laboratory of Geriatric Immunology and Nutrition Therapy, Hefei 230027, China. Electronic address: drshiyin@ustc.edu.cn.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2024 Aug 14; Vol. 32 (8), pp. 1331-1346.e6. Date of Electronic Publication: 2024 Jul 02.
DOI:	10.1016/j.chom.2024.06.008
Abstrakt:	The gut microbiota and diet-induced changes in microbiome composition have been linked to various liver diseases, although the specific microbes and mechanisms remain understudied. Alcohol-related liver disease (ALD) is one such disease with limited therapeutic options due to its complex pathogenesis. We demonstrate that a diet rich in soluble dietary fiber increases the abundance of Bacteroides acidifaciens (B. acidifaciens) and alleviates alcohol-induced liver injury in mice. B. acidifaciens treatment alone ameliorates liver injury through a bile salt hydrolase that generates unconjugated bile acids to activate intestinal farnesoid X receptor (FXR) and its downstream target, fibroblast growth factor-15 (FGF15). FGF15 promotes hepatocyte expression of ornithine aminotransferase (OAT), which facilitates the metabolism of accumulated ornithine in the liver into glutamate, thereby providing sufficient glutamate for ammonia detoxification via the glutamine synthesis pathway. Collectively, these findings uncover a potential therapeutic strategy for ALD involving dietary fiber supplementation and B. acidifaciens. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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