From whence it came: Mitochondrial mRNA leaves, a protein returns.
| Autor: | Janssen KA; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Children's Hospital of Philadelphia's Cell and Gene Therapy Collaborative, Philadelphia, PA, USA. Electronic address: janssenk2@chop.edu., Song A; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cell metabolism [Cell Metab] 2024 Jul 02; Vol. 36 (7), pp. 1433-1435. |
| DOI: | 10.1016/j.cmet.2024.06.002 |
| Abstrakt: | Small peptides have previously been reported to be encoded in mitochondrial rRNA and translated by cytosolic ribosomes. In this issue of Cell Metabolism, Hu et al. use mass spectrometry to identify a cytosolically translated protein, encoded instead in mitochondrial mRNA, that is surprisingly targeted back into the mitochondrial matrix. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|