| Autor: |
Yu Z; Institute of Environmental Medicine and., Kebede Merid S; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Bellander T; Institute of Environmental Medicine and., Bergström A; Institute of Environmental Medicine and.; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden., Eneroth K; Stockholms Luft-och Bulleranalys, Environment and Health Administration, Stockholm, Sweden., Merritt AS; Institute of Environmental Medicine and.; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden., Ödling M; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Kull I; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden., Ljungman P; Institute of Environmental Medicine and.; Department of Cardiology, Danderyd Hospital, Stockholm, Sweden., Klevebro S; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden., Stafoggia M; Institute of Environmental Medicine and.; Department of Epidemiology, Lazio Regional Health Service/Azienda Sanitaria Locale Roma 1, Rome, Italy., Janson C; Respiratory, Allergy, and Sleep Research, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; and., Wang G; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China., Pershagen G; Institute of Environmental Medicine and., Melén E; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden., Gruzieva O; Institute of Environmental Medicine and.; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden. |
| Abstrakt: |
Rationale: The benefits of improved air quality on asthma remain understudied. Objectives: Our aim was to investigate associations of changes in ambient air pollution with incident asthma from school age until young adulthood in an area with mostly low air pollution levels. Methods: Participants in the BAMSE (Swedish abbreviation for Children, Allergy, Environment, Stockholm, Epidemiology) birth cohort from Stockholm without asthma before the 8-year follow-up were included ( N = 2,371). We estimated the association of change in individual-level air pollutant exposure (particulate matter with an aerodynamic diameter ≤ 2.5 μm [PM 2.5 ] and ≤ 10 μm [PM 10 ], black carbon [BC], and nitrogen oxides [NO x ]) from the first year of life to the 8-year follow-up with asthma incidence from the 8-year until the 24-year follow-up. Multipollutant trajectories were identified using the group-based multivariate trajectory model. We also used parametric G-computation to quantify the asthma incidence under different hypothetical interventions regarding air pollution levels. Results: Air pollution levels at residency decreased during the period, with median reductions of 5.6% for PM 2.5 , 3.1% for PM 10 , 5.9% for BC, and 26.8% for NO x . A total of 395 incident asthma cases were identified from the 8-year until the 24-year follow-up. The odds ratio for asthma was 0.89 (95% confidence interval [CI], 0.80-0.99) for each interquartile range reduction in PM 2.5 (equal to 8.1% reduction). Associations appeared less clear for PM 10 , BC, and NO x . Five multipollutant trajectories were identified; the largest reduction trajectory displayed the lowest odds of asthma (odds ratio, 0.55; 95% CI, 0.31-0.98) compared with the lowest reduction trajectory. If the PM 2.5 exposure had not declined up to the 8-year follow-up, the hypothetical asthma incidence was estimated to have been 10.9% higher (95% CI, 0.8-20.8%). Conclusions: A decrease in PM 2.5 levels during childhood was associated with a lower risk of incident asthma from school age to young adulthood in an area with relatively low air pollution levels, suggesting broad respiratory health benefits from improved air quality. |
