Histological evaluation of different concentrations of hyaluronic-acid-added zinc oxide eugenol on rat molar pulp.

Autor: Bektas I; Department of Pediatric Dentistry, Institute of Health Sciences, Marmara University, Basibuyuk, Saglik Yerleskesi 9/3 Maltepe, 34854, Istanbul, Turkey. irmakbektas@yahoo.com., Hazar Yoruc AB; Department of Metallurgical and Materials Engineering, Yildiz Technical University, Davutpasa Cad. No.127 Esenler,, 34210, Istanbul, Turkey., Cinel L; Department of Pathology, School of Medicine, Marmara University, Pendik Egitim Arastirma Hastanesi, Ust Kaynarca, Pendik, Istanbul, Turkey., Ekinci M; Department of Pediatric Dentistry, Institute of Health Sciences, Marmara University, Basibuyuk, Saglik Yerleskesi 9/3 Maltepe, 34854, Istanbul, Turkey., Horoz SE; Department of Pathology, School of Medicine, Marmara University, Pendik Egitim Arastirma Hastanesi, Ust Kaynarca, Pendik, Istanbul, Turkey., Turet DM; Experimental Animal Implementation and Research Center, Medical School, Marmara University, Basibuyuk, Maltepe, 34854, Istanbul, Turkey., Mentes A; Department of Pediatric Dentistry, Institute of Health Sciences, Marmara University, Basibuyuk, Saglik Yerleskesi 9/3 Maltepe, 34854, Istanbul, Turkey.; Department of Pediatric Dentistry, School of Dentistry, Marmara University, Basibuyuk, Saglik Yerleskesi 9/3 Maltepe, 34854, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Odontology [Odontology] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03.
DOI: 10.1007/s10266-024-00973-7
Abstrakt: Hyaluronic acid (HA), known for diverse properties, was investigated for its potential in dental pulp therapy. This study investigated the potential of HA in dental pulp therapy by examining the physical properties and effects of zinc oxide eugenol (ZOE) pulpotomy materials containing varying HA concentrations on rat molar teeth. In vitro tests assessed compressive strength and hardness of ZOE materials blended with HA (0.5%, 1%, 3%) and HA gels (0.54%, 0.8%). 120 samples, encompassing the control group, underwent compressive strength testing, while 60 samples were designated for hardness assessment. In vivo experiments on rat molars studied histological effects of HA-containing ZOE on dental pulp over 1 week and 1 month. Gels with HA concentrations of 0.5%, 1%, and 0.54% were used in pulpotomy on 22 rats. Each rat underwent the procedure on four teeth, with one tooth serving as a control, totaling 88 teeth subjected to the intervention. In the analyses, SPSS 22.0 was used and the significance level was set at P = 0.05. Findings showed that HA at 0.5% maintained compressive strength, but higher concentrations decreased mechanical properties significantly (P = 0.001). Histological assessments indicated better outcomes with lower HA concentrations in terms of odontoblast layer continuity (P = 0.005 at 1 month) and pulp vitality (P = 0.001 at 1 week and P = 0.018 at 1 month). The study suggests HA holds promise for pulpotomy and regenerative endodontic treatments, but further research is needed to understand long-term clinical implications.
(© 2024. The Author(s).)
Databáze: MEDLINE
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