Advances in targeted liquid chromatography-tandem mass spectrometry methods for endocannabinoid and N-acylethanolamine quantification in biological matrices: A systematic review.

Autor: Amir Hamzah K; School of Psychology and Counselling, Department of Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia., Turner N; The Centre for Children's Health Research, Queensland University of Technology, Kelvin Grove, Queensland, Australia., Nichols D; Central Science Laboratory, Science and Engineering, University of Tasmania, Hobart, Tasmania, Australia., Ney LJ; School of Psychology and Counselling, Department of Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
Jazyk: angličtina
Zdroj: Mass spectrometry reviews [Mass Spectrom Rev] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03.
DOI: 10.1002/mas.21897
Abstrakt: Liquid chromatography paired with tandem mass spectrometry (LC-MS/MS) is the gold standard in measurement of endocannabinoid concentrations in biomatrices. We conducted a systematic review of literature to identify advances in targeted LC-MS/MS methods in the period 2017-2024. We found that LC-MS/MS methods for endocannabinoid quantification are relatively consistent both across time and across biomatrices. Recent advances have primarily been in three areas: (1) sample preparation techniques, specific to the chosen biomatrix; (2) the range of biomatrices tested, recently favoring blood matrices; and (3) the breadth of endocannabinoid and endocannabinoid-like analytes incorporated into assays. This review provides a summary of the recent literature and a guide for researchers looking to establish the best methods for quantifying endocannabinoids in a range of biomatrices.
(© 2024 The Author(s). Mass Spectrometry Reviews published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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