Evaluation of clopidogrel response in healthy cats using a novel viscoelastic test and thromboelastography.
| Autor: | Rosati T; WR Pritchard Veterinary Medical Teaching Hospital, University of California Davis, Davis, CA, United States.; Department for Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., Jandrey KE; Department of Surgical and Radiological Sciences, University of California Davis, Davis, CA, United States., Stern JA; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.; Department of Medicine and Epidemiology, University of California Davis, Davis, CA, United States., Nguyen N; Department of Surgical and Radiological Sciences, University of California Davis, Davis, CA, United States., Li RHL; Department of Surgical and Radiological Sciences, University of California Davis, Davis, CA, United States.; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in veterinary science [Front Vet Sci] 2024 Jun 18; Vol. 11, pp. 1371781. Date of Electronic Publication: 2024 Jun 18 (Print Publication: 2024). |
| DOI: | 10.3389/fvets.2024.1371781 |
| Abstrakt: | Introduction: Cats with cardiomyopathy face an increased risk of arterial thromboembolism (ATE). Although clopidogrel is frequently utilized to mitigate this risk, feline responses to this therapy exhibit variability. This study evaluated 2 viscoelastic devices, thromboelastography (TEG) and Viscoelastic Coagulation Monitor (VCM), for monitoring clopidogrel in cats in comparison to light transmission aggregometry (LTA). Methods: Twenty-eight healthy cats received clopidogrel for 7 days. Blood was collected at baseline and after treatment for analysis by TEG, VCM, and LTA. Results: On LTA, maximum amplitude, slope, and area under the curve (AUC) significantly decreased after treatment ( p < 0.0001). On VCM, maximum clot firmness (MCF) significantly increased after treatment ( p = 0.002). On TEG, R-time significantly prolonged ( p = 0.024), while K and alpha angle significantly changed ( p = 0.0002 and p = 0.0014, respectively). There was a moderate negative correlation between TEG R-time and LTA AUC ( r = -0.39, p = 0.042). Eight cats were identified as non-responders to clopidogrel. Of the 8 non-responders, 6 (75%) had shortened R time after treatment. VCM appeared to be less discriminatory in identifying non-responders. Discussion: LTA remained the gold standard of monitoring clopidogrel treatment in cats. Unexpected changes on VCM and TEG were likely related to high interindividual and assay variability and increased sensitivity of feline platelets. R-time on TEG may have potential utility for point-of-care monitoring of clopidogrel response in cats. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Rosati, Jandrey, Stern, Nguyen and Li.) |
| Databáze: | MEDLINE |
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