Exploring the therapeutic potential of Caralluma fimbriata for antioxidant and diabetes management: a 28-day rat model study.
| Autor: | Arif A; Department of Human Nutrition, Faculty of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan., Sultan MT; Department of Human Nutrition, Faculty of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan., Nazir F; Department of Nutritional Sciences, Knowledge Unit of Health Sciences, University of Management and Technology, Sialkot Campus, Sialkot 51310, Pakistan., Ahmad K; Department of Chemistry, Emerson University Multan (EUM), Multan 60000, Pakistan., Kashif M; Department of Chemistry, Emerson University Multan (EUM), Multan 60000, Pakistan., Ahmad MM; Institute of Chemical Sciences, Bahauddin Zakariya University Multan, Multan 60800, Pakistan., Shehzad FK; Department of Chemistry, Emerson University Multan (EUM), Multan 60000, Pakistan., Nazir MA; Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan., Mushtaq S; Department of Chemistry, University of Management and Technology, Sialkot campus, Sialkot 51310, Pakistan., Khalid MU; Department of Human Nutrition, Faculty of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan., Noman AM; Department of Human Nutrition, Faculty of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan., Raza H; Department of Human Nutrition, Faculty of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan., Israr M; Department of Human Nutrition, Faculty of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan., Sohail H; Department of Human Nutrition, Faculty of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan., Rocha JM; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, Porto 4169-005, Portugal.; LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, Porto 4200-465, Portugal.; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, Porto 4200-465, Portugal. |
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| Jazyk: | angličtina |
| Zdroj: | Toxicology research [Toxicol Res (Camb)] 2024 Jul 01; Vol. 13 (4), pp. tfae094. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024). |
| DOI: | 10.1093/toxres/tfae094 |
| Abstrakt: | This study evaluated the anti-oxidant and anti-diabetic potential of Caralluma fimbriata (CF) in 28-days rat modelling trial. Diabetes is a chronic disorder characterized by elevated blood glucose levels and insulin resistance and cause microvascular and macrovascular issues. Caralluma fimbriata was evaluated for its nutritional composition along with anti-oxidant potential of CF powder (CFP) and CF extract (CFE) using total phenolic contents (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) assays. Furthermore, anti-diabetic potential was computed by dividing rats into four groups of 5 individuals each. Rats of Group I was non-diabetic and no supplementation was given while rats of group II were diabetic and no supplementation was given. While group III and group IV rats were diabetic and received CFP and CFE supplementation respectively. CF powder's TPC, and DPPH and FRAP activity were observed maximum at 44.17 ± 0.006 (μg (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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