Adverse drug reactions, adherence, and virologic outcomes in adult patients on dolutegravir-based antiretroviral therapy at a tertiary hospital, southeast Nigeria.

Autor: Ogbonnaya LU; Department of Community Medicine, College of Health Sciences Ebonyi State University Abakaliki Nigeria.; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Onah CK; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Azuogu BN; Department of Community Medicine, College of Health Sciences Ebonyi State University Abakaliki Nigeria.; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Akpa CO; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Okeke KC; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Nwachukwu VN; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Stephen-Emeya A; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Asaga IU; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria., Umeokonkwo CD; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
Jazyk: angličtina
Zdroj: Ghana medical journal [Ghana Med J] 2024 Mar; Vol. 58 (1), pp. 101-108.
DOI: 10.4314/gmj.v58i1.14
Abstrakt: Objective: To assess the adherence, adverse drug reactions (ADR), and virologic outcomes of dolutegravir-based antiretroviral therapy.
Design: This was a retrospective chart review.
Setting: A tertiary health facility-based study in Abakaliki, Nigeria.
Participants: Five hundred and fifteen (515) adult patients on dolutegravir were selected using a Random Number Generator. Demographic and clinical data were extracted from patients' case notes and analysed with IBM-SPSS version-25.
Main Outcome Measures: Adherence to dolutegravir, ADRs, virologic outcome, and change in Body Mass Index (BMI) were estimated.
Results: The mean age of the patients was 45.5±10.8 years; 68.2% of them were females; 97.1% of them had good self-reported adherence. The majority (82.9%) of them reported no ADRs and among those (17.1%) that did, headache (9.7%), body-itching (3.1%), and skin rash (2.7%) dominated. Most achieved viral suppression (94.4%) and did not have detectable viral particles (57.4%). There was a significant increase in the BMI of the patients with a mean weight increase of 0.9kg, a mean BMI increase of 0.3 kg/m 2 , and a 2.6% increase in the prevalence of overweight and obesity.
Conclusions: Patients on dolutegravir reported low ADRs, good self-reported adherence, and a high viral suppression rate. However, dolutegravir is associated with weight gain. We recommend widespread use and more population-wide studies to elucidate the dolutegravir-associated weight gain.
Funding: None declared.
Competing Interests: Conflict of interest: None declared.
(Copyright © The Author(s).)
Databáze: MEDLINE
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