Investigating the neural mechanisms of transcranial direct current stimulation effects on human cognition: current issues and potential solutions.

Autor:	Meinzer M; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Shahbabaie A; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Antonenko D; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Blankenburg F; Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany., Fischer R; Department of Psychology, University of Greifswald, Greifswald, Germany., Hartwigsen G; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Wilhelm Wundt Institute for Psychology, Leipzig University, Leipzig, Germany., Nitsche MA; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany.; German Center for Mental Health (DZPG), Bochum, Germany.; Bielefeld University, University Hospital OWL, Protestant Hospital of Bethel Foundation, University Clinic of Psychiatry and Psychotherapy, Bielefeld, Germany., Li SC; Chair of Lifespan Developmental Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany., Thielscher A; Section for Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark., Timmann D; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany., Waltemath D; Core Unit Data Integration Center, University Medicine Greifswald, Greifswald, Germany., Abdelmotaleb M; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Kocataş H; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Caisachana Guevara LM; Department of Psychology, University of Greifswald, Greifswald, Germany., Batsikadze G; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany., Grundei M; Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany., Cunha T; Section for Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Hayek D; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Turker S; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Wilhelm Wundt Institute for Psychology, Leipzig University, Leipzig, Germany., Schlitt F; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany., Shi Y; Chair of Lifespan Developmental Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany., Khan A; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany., Burke M; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany., Riemann S; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Niemann F; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Flöel A; Department of Neurology, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE Site Greifswald), Greifswald, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Jun 18; Vol. 18, pp. 1389651. Date of Electronic Publication: 2024 Jun 18 (Print Publication: 2024).
DOI:	10.3389/fnins.2024.1389651
Abstrakt:	Transcranial direct current stimulation (tDCS) has been studied extensively for its potential to enhance human cognitive functions in healthy individuals and to treat cognitive impairment in various clinical populations. However, little is known about how tDCS modulates the neural networks supporting cognition and the complex interplay with mediating factors that may explain the frequently observed variability of stimulation effects within and between studies. Moreover, research in this field has been characterized by substantial methodological variability, frequent lack of rigorous experimental control and small sample sizes, thereby limiting the generalizability of findings and translational potential of tDCS. The present manuscript aims to delineate how these important issues can be addressed within a neuroimaging context, to reveal the neural underpinnings, predictors and mediators of tDCS-induced behavioral modulation. We will focus on functional magnetic resonance imaging (fMRI), because it allows the investigation of tDCS effects with excellent spatial precision and sufficient temporal resolution across the entire brain. Moreover, high resolution structural imaging data can be acquired for precise localization of stimulation effects, verification of electrode positions on the scalp and realistic current modeling based on individual head and brain anatomy. However, the general principles outlined in this review will also be applicable to other imaging modalities. Following an introduction to the overall state-of-the-art in this field, we will discuss in more detail the underlying causes of variability in previous tDCS studies. Moreover, we will elaborate on design considerations for tDCS-fMRI studies, optimization of tDCS and imaging protocols and how to assure high-level experimental control. Two additional sections address the pressing need for more systematic investigation of tDCS effects across the healthy human lifespan and implications for tDCS studies in age-associated disease, and potential benefits of establishing large-scale, multidisciplinary consortia for more coordinated tDCS research in the future. We hope that this review will contribute to more coordinated, methodologically sound, transparent and reproducible research in this field. Ultimately, our aim is to facilitate a better understanding of the underlying mechanisms by which tDCS modulates human cognitive functions and more effective and individually tailored translational and clinical applications of this technique in the future. Competing Interests: MAN is in the scientific advisory board of Neuroelectrics and Précis’s. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer BL declared a past co-authorship with the authors AF and MAN to the handling editor. (Copyright © 2024 Meinzer, Shahbabaie, Antonenko, Blankenburg, Fischer, Hartwigsen, Nitsche, Li, Thielscher, Timmann, Waltemath, Abdelmotaleb, Kocataş, Caisachana Guevara, Batsikadze, Grundei, Cunha, Hayek, Turker, Schlitt, Shi, Khan, Burke, Riemann, Niemann and Flöel.)
Databáze:	MEDLINE
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