Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy.

Autor:	Imkongyanger; Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy., Richa K; Department of Biotechnology, St. Joseph University, Chumoukedima, 797115, Nagaland, India., Lotha TN; Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy., Ao K; Department of Environmental Science, Nagaland University, Lumami, 798627, Nagaland, India., Rudithongru L; Department of Environmental Science, Nagaland University, Lumami, 798627, Nagaland, India., Nakro V; Department of Environmental Science, Nagaland University, Lumami, 798627, Nagaland, India., Ritse V; Department of Environmental Science, Nagaland University, Lumami, 798627, Nagaland, India., Namsa ND; Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, 784028, Assam, India., Pankaj PP; Department of Zoology, Nagaland University, Lumami, 798627, Nagaland, India., Sinha UB; Department of Chemistry, Nagaland University, Lumami, 798627, Nagaland, India., Jamir L; Department of Environmental Science, Nagaland University, Lumami, 798627, Nagaland, India.
Jazyk:	angličtina
Zdroj:	Endocrine, metabolic & immune disorders drug targets [Endocr Metab Immune Disord Drug Targets] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02.
DOI:	10.2174/0118715303287962240621053459
Abstrakt:	Background: Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals. Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic agents for T2DM management. Aims: The present study introduces an efficient one-pot synthesis method for the production of symmetrical guanidine compounds. Methods: This synthesis involves the reaction of isothiocyanates with secondary amines, employing an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide (TBPTB). Results: A comprehensive assessment of the biological activity of the synthesized guanidine compounds, specifically in the context of T2DM, has been rigorously conducted. Conclusion: Additionally, computational analyses have unveiled their substantial potential as promising antidiabetic agents. Results highlight the relevance of these compounds in the ongoing pursuit of novel therapeutic solutions for T2DM. . (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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