The protective effects of repetitive transcranial magnetic stimulation with different high frequencies on motor functions in MPTP/probenecid induced Parkinsonism mouse models.

Autor: Lyu Z; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.; Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.; The Ganzhou Key Laboratory of Noninvasive Neuromodulation, Ganzhou, China.; Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China., Xiao G; Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China., Xie D; Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China., Huang D; Department of Basic Medical Sciences, Gannan Medical University, Ganzhou, China., Chen Y; Department of International Exchange and Cooperation, Jiangxi University of Chinese Medicine, Nanchang, China., Wu C; Department of Health Statistics, School of Public Health & Health Management, Gannan Medical University, Ganzhou, China., Lai Y; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.; The Ganzhou Key Laboratory of Noninvasive Neuromodulation, Ganzhou, China., Song Z; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.; The Ganzhou Key Laboratory of Noninvasive Neuromodulation, Ganzhou, China., Huang L; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.; The Ganzhou Key Laboratory of Noninvasive Neuromodulation, Ganzhou, China., Ming H; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.; The Ganzhou Key Laboratory of Noninvasive Neuromodulation, Ganzhou, China., Jiang Y; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.; The Ganzhou Key Laboratory of Noninvasive Neuromodulation, Ganzhou, China., Wang J; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.; The Ganzhou Key Laboratory of Noninvasive Neuromodulation, Ganzhou, China., Chen R; Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China., Luo W; Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2024 Jul; Vol. 14 (7), pp. e3605.
DOI: 10.1002/brb3.3605
Abstrakt: Background: High-frequency repeated transcranial magnetic stimulation (rTMS) stimulating the primary motor cortex (M1) is an alternative, adjunctive therapy for improving the motor symptoms of Parkinson's disease (PD). However, whether the high frequency of rTMS positively correlates to the improvement of motor symptoms of PD is still undecided. By controlling for other parameters, a disease animal model may be useful to compare the neuroprotective effects of different high frequencies of rTMS.
Objective: The current exploratory study was designed to compare the protective effects of four common high frequencies of rTMS (5, 10, 15, and 20 Hz) and iTBS (a special form of high-frequency rTMS) and explore the optimal high-frequency rTMS on an animal PD model.
Methods: Following high frequencies of rTMS application (twice a week for 5 weeks) in a MPTP/probenecid-induced chronic PD model, the effects of the five protocols on motor behavior as well as dopaminergic neuron degeneration levels were identified. The underlying molecular mechanisms were further explored.
Results: We found that all the high frequencies of rTMS had protective effects on the motor functions of PD models to varying degrees. Among them, the 10, 15, and 20 Hz rTMS interventions induced comparable preservation of motor function through the protection of nigrostriatal dopamine neurons. The enhancement of brain-derived neurotrophic factor (BDNF), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT-2) and the suppression of TNF-α and IL-1β in the nigrostriatum were involved in the process. The efficacy of iTBS was inferior to that of the above three protocols. The effect of 5 Hz rTMS protocol was weakest.
Conclusions: Combined with the results of the present study and the possible side effects induced by rTMS, we concluded that 10 Hz might be the optimal stimulation frequency for preserving the motor functions of PD models using rTMS treatment.
(© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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