Exploring the interplay of psychiatric symptoms, antipsychotic medications, side effects, employment status, and quality of life in Chronic Schizophrenia.

Autor: Zhou DN; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Yang X; The First Psychiatric Hospital of Harbin, Harbin, Heilongjiang Province, China., Wang W; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Jin WQ; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Tang YL; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.; Mental Health Service Line, Atlanta VA Medical Center, Decatur, GA, 30033, USA., Zheng Z; Huai'an No. 3 People's Hospital, Huaian, Jiangsu Province, China. zhengzhi665588@163.com., Ren Y; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China. renyanping@ccmu.edu.cn.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. renyanping@ccmu.edu.cn.
Jazyk: angličtina
Zdroj: BMC psychiatry [BMC Psychiatry] 2024 Jul 02; Vol. 24 (1), pp. 484. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1186/s12888-024-05929-3
Abstrakt: Background: Many factors contribute to quality of life (QoL) in patients with schizophrenia, yet limited research examined these factors in patients in China. This cross-sectional study explores subjective QoL and its associated factors in patients.
Methods: The QoL was assessed using the Schizophrenia Quality of Life Scale (SQLS). Clinical symptoms were evaluated using the Brief Psychiatric Rating Scale (BPRS) and seven factors were extracted. Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder Scale (GAD-7) were used to assess depression and anxiety. Cognitive impairment was assessed using the Ascertain Dementia 8 (AD8). The Treatment Emergent Symptom Scale (TESS) and Rating Scale for Extrapyramidal Side Effects (RSESE) were used to evaluate the side effects of medications.
Results: We recruited 270 patients (male:142,52.6%, mean age:41.9 ± 9.4 years). Positive correlations were observed between SQLS and its subdomains with the total score of BPRS, PHQ-9, GAD-7, AD8, TESS, and RSESE (all P < 0.005). Patients who were taking activating second-generation antipsychotics (SGAs) had lower scores on total SQLS, Motivation/ Energy domain of SQLS (SQLS-ME) as well as Symptoms/ Side effects domain of SQLS (SQLS-SS) compared to those taking non-activating SGAs (all P < 0.005). Multiple regression analysis showed that depressive/ anxiety symptoms and cognitive impairment had significant negative effects on QoL (P ≤ 0.001), while activating SGAs had a positive effect (P < 0.005). Blunted affect and unemployment were inversely associated with the motivation/energy domain (P < 0.001).
Conclusion: Our findings emphasize the important role of depression/anxiety symptoms and cognitive impairment in the QoL of patients with chronic schizophrenia. Activating SGAs and employment may improve the QoL of these individuals.
Trial Registration: This protocol was registered at chictr.org.cn (Identifier: ChiCTR2100043537).
(© 2024. The Author(s).)
Databáze: MEDLINE
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