SARS-CoV-2 seroprevalence among Beninese pregnant women in the third year of the pandemic.

Autor: Figueroa-Romero A; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Barcelona, Spain. antia.figueroa@isglobal.org.; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública, CIBERESP, Madrid, Spain. antia.figueroa@isglobal.org., Atchadé A; Institut de Recherche Clinique du Bénin, Abomey-Calavi, Benin., Yadouleton A; Laboratoire des fièvres hémorragiques virales du Bénin, Ministère de la Santé du Bénin, Cotonou, 01BP918, Bénin., Fiogbe M; Institut de Recherche Clinique du Bénin, Abomey-Calavi, Benin., Bonnet E; Institut de recherche pour le développement PRODIG UMR 215, CNRS Université Paris 1 Panthéon- Sorbonne, AgroParisTech 5, cours des Humanités, Aubervilliers, Île-de-France, F-93 322, France., Yovo E; Institut de Recherche Clinique du Bénin, Abomey-Calavi, Benin., Accrombessi M; Institut de Recherche Clinique du Bénin, Abomey-Calavi, Benin.; Faculty of Infectious and Tropical Diseases, Disease Control Department, London School of Hygiene & Tropical Medicine, London, UK.; Population Services International, Malaria Department, Country-Based Global Employee, Cotonou, Benin., Hounsa S; Institut de Recherche Clinique du Bénin, Abomey-Calavi, Benin., Paper T; Biosynex S.A, 22 boulevard Sebastien Brant, Illkirch Graffenstaden, Strasbourg, F-67400, France., Dupont R; Biosynex S.A, 22 boulevard Sebastien Brant, Illkirch Graffenstaden, Strasbourg, F-67400, France., Gaudart J; Aix Marseille Univ, IRD, INSERM, SESSTIM, ISSPAM, AP-HM, Hop La Timone, BioSTIC, Biostatistic and ICT, Marseille, France., Le Hesran JY; Institut de Recherche pour le Développement, MERIT UMR216, Université Paris-Cité, Faculté de pharmacie, laboratoire de parasitologie, Paris, France., Massougbodji A; Institut de Recherche Clinique du Bénin, Abomey-Calavi, Benin., Cottrell G; Institut de Recherche pour le Développement, MERIT UMR216, Université Paris-Cité, Faculté de pharmacie, laboratoire de parasitologie, Paris, France., González R; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Barcelona, Spain.; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública, CIBERESP, Madrid, Spain.; Department of Medicine, Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique.
Jazyk: angličtina
Zdroj: BMC public health [BMC Public Health] 2024 Jul 02; Vol. 24 (1), pp. 1762. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1186/s12889-024-19087-4
Abstrakt: Background: Pregnant women are a vulnerable population to COVID-19 given an increased susceptibility to severe SARS-CoV-2 infection and pregnancy complications. However, few SARS-CoV-2 serological surveys have been performed among this population to assess the extent of the infection in sub-Saharan countries. The objectives of this study were to determine SARS-CoV-2 seroprevalence among Beninese pregnant women, to identify spatial seropositivity clusters and to analyse factors associated with the infection.
Methods: A cross-sectional study including women in their third trimester of pregnancy attending the antenatal care (ANC) clinics at Allada (south Benin) and Natitingou (north Benin) was conducted. Rapid diagnostic tests (RDT) for detection of IgG/IgM against the SARS-CoV-2 spike protein were performed using capillary blood. Seroprevalence of SARS-CoV-2 antibodies and associations between SARS-CoV-2 serostatus and maternal characteristics were analyzed by multivariate logistic regression. Spatial analyses were performed using the spatial scan statistics to identify spatial clusters of SARS-CoV-2 infection.
Results: A total of 861 pregnant women were enrolled between May 4 and June 29, 2022. 58/861 (6.7%) participants reported having received COVID-19 vaccine. None of the participants had been diagnosed with COVID-19 during their pregnancy. SARS-CoV-2 antibodies were detected in 607/802 (75.7%; 95% CI 72.56%-78.62%) of unvaccinated participants. Several urban and rural spatial clusters of SARS-CoV-2 cases were identified in Allada and one urban spatial cluster was identified in Natitingou. Unvaccinated participants from Allada with at least one previous morbidity were at a three-times higher risk of presenting SARS-CoV-2 antibodies (OR = 2.89; 95%CI 1.19%-7.00%).
Conclusion: Three out of four pregnant women had SARS-CoV-2 antibodies, suggesting a high virus circulation among pregnant women in Benin, while COVID-19 vaccination coverage was low. Pregnant women with comorbidities may be at increased risk of SARS-CoV-2 infection. This population should be prioritized for COVID-19 diagnosis and vaccination in order to prevent its deleterious effects.
Trial Registration: NCT06170320 (retrospectively registered on December 21, 2023).
(© 2024. The Author(s).)
Databáze: MEDLINE
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