Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals.

Autor: Xiong C; Division of Biostatistics, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Luo J; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource, Washington University School of Medicine, St. Louis, MO, USA., Wolk DA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shaw LM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Roberson ED; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Murchison CF; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Henson RL; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Benzinger TLS; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA., Bui Q; Division of Biostatistics, Washington University, St. Louis, MO, USA., Agboola F; Division of Biostatistics, Washington University, St. Louis, MO, USA., Grant E; Division of Biostatistics, Washington University, St. Louis, MO, USA., Gremminger EN; Division of Biostatistics, Washington University, St. Louis, MO, USA., Moulder KL; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Geldmacher DS; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Clay OJ; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA., Babulal G; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Cruchaga C; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Bateman RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Schindler SE; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. schindler.s.e@wustl.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jul 02; Vol. 15 (1), pp. 5539. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1038/s41467-024-49859-w
Abstrakt: Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers in participants who identify their race as either Black or white. Plasma samples from 324 Black and 1,547 white participants underwent analysis with C 2 N Diagnostics' PrecivityAD test for Aβ42 and Aβ40. Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology. Interestingly, this difference resulted from lower average levels of plasma Aβ40 in Black participants. Despite the differences, Black and white individuals had similar longitudinal rates of change in Aβ42/40, consistent with a similar rate of amyloid accumulation. Our results agree with multiple recent studies demonstrating a lower prevalence of amyloid pathology in Black individuals, and additionally suggest that amyloid accumulates consistently across both groups.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: