Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals.
Autor: | Xiong C; Division of Biostatistics, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Luo J; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource, Washington University School of Medicine, St. Louis, MO, USA., Wolk DA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shaw LM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Roberson ED; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Murchison CF; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Henson RL; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Benzinger TLS; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA., Bui Q; Division of Biostatistics, Washington University, St. Louis, MO, USA., Agboola F; Division of Biostatistics, Washington University, St. Louis, MO, USA., Grant E; Division of Biostatistics, Washington University, St. Louis, MO, USA., Gremminger EN; Division of Biostatistics, Washington University, St. Louis, MO, USA., Moulder KL; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Geldmacher DS; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Clay OJ; Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA., Babulal G; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Cruchaga C; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Bateman RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Schindler SE; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. schindler.s.e@wustl.edu. |
---|---|
Jazyk: | angličtina |
Zdroj: | Nature communications [Nat Commun] 2024 Jul 02; Vol. 15 (1), pp. 5539. Date of Electronic Publication: 2024 Jul 02. |
DOI: | 10.1038/s41467-024-49859-w |
Abstrakt: | Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers in participants who identify their race as either Black or white. Plasma samples from 324 Black and 1,547 white participants underwent analysis with C (© 2024. The Author(s).) |
Databáze: | MEDLINE |
Externí odkaz: |