Perirhinal cortex learns a predictive map of the task environment.

Autor: Lee DG; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.; Center for Neurophotonics, Boston University, Boston, MA, 02215, USA., McLachlan CA; Center for Neurophotonics, Boston University, Boston, MA, 02215, USA.; Department of Biology, Boston University, Boston, MA, 02215, USA., Nogueira R; Center for Theoretical Neuroscience, Columbia University, New York, NY, 10027, USA.; Department of Neuroscience, Columbia University, New York, NY, 10027, USA., Kwon O; Center for Neurophotonics, Boston University, Boston, MA, 02215, USA.; Department of Biology, Boston University, Boston, MA, 02215, USA., Carey AE; Center for Neurophotonics, Boston University, Boston, MA, 02215, USA.; Department of Biology, Boston University, Boston, MA, 02215, USA., House G; Department of Biology, Boston University, Boston, MA, 02215, USA., Lagani GD; Department of Biology, Boston University, Boston, MA, 02215, USA., LaMay D; Department of Biology, Boston University, Boston, MA, 02215, USA., Fusi S; Center for Theoretical Neuroscience, Columbia University, New York, NY, 10027, USA.; Department of Neuroscience, Columbia University, New York, NY, 10027, USA., Chen JL; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA. jerry@chen-lab.org.; Center for Neurophotonics, Boston University, Boston, MA, 02215, USA. jerry@chen-lab.org.; Department of Biology, Boston University, Boston, MA, 02215, USA. jerry@chen-lab.org.; Center for Systems Neuroscience, Boston University, Boston, MA, 02215, USA. jerry@chen-lab.org.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jul 02; Vol. 15 (1), pp. 5544. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1038/s41467-024-47365-7
Abstrakt: Goal-directed tasks involve acquiring an internal model, known as a predictive map, of relevant stimuli and associated outcomes to guide behavior. Here, we identified neural signatures of a predictive map of task behavior in perirhinal cortex (Prh). Mice learned to perform a tactile working memory task by classifying sequential whisker stimuli over multiple training stages. Chronic two-photon calcium imaging, population analysis, and computational modeling revealed that Prh encodes stimulus features as sensory prediction errors. Prh forms stable stimulus-outcome associations that can progressively be decoded earlier in the trial as training advances and that generalize as animals learn new contingencies. Stimulus-outcome associations are linked to prospective network activity encoding possible expected outcomes. This link is mediated by cholinergic signaling to guide task performance, demonstrated by acetylcholine imaging and systemic pharmacological perturbation. We propose that Prh combines error-driven and map-like properties to acquire a predictive map of learned task behavior.
(© 2024. The Author(s).)
Databáze: MEDLINE
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