Clinical-laboratory characteristics predictive of COVID-19 severity: a prospective hospital cohort, in Pernambuco, Northeast Brazil.

Autor: Brito C; Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. carlos.brito@ufpe.br.; Department of Internal Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. carlos.brito@ufpe.br.; Department of Immunology, Autoimune Research Institute, Recife, Pernambuco, Brazil. carlos.brito@ufpe.br., de Araujo Mariz C; Aggeu Magalhães Institute, Oswaldo Cruz Foundation - FIOCRUZ, Recife, Pernambuco, Brazil., Freitas de Oliveira França R; Aggeu Magalhães Institute, Oswaldo Cruz Foundation - FIOCRUZ, Recife, Pernambuco, Brazil., Lopes EP; Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.; Department of Internal Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife, Brazil., Silva LE; Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife, Brazil., Neto RL; Aggeu Magalhães Institute, Oswaldo Cruz Foundation - FIOCRUZ, Recife, Pernambuco, Brazil., Viana IF; Aggeu Magalhães Institute, Oswaldo Cruz Foundation - FIOCRUZ, Recife, Pernambuco, Brazil., Montarroyos U; Aggeu Magalhães Institute, Oswaldo Cruz Foundation - FIOCRUZ, Recife, Pernambuco, Brazil., Duarte C; Servidores do Estado Hospital, Recife, Pernambuco, Brazil., Lacerda HR; Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife, Brazil., de Brito Ximenes P; Servidores do Estado Hospital, Recife, Pernambuco, Brazil., de Oliveira Viana RC; Servidores do Estado Hospital, Recife, Pernambuco, Brazil., Lima RGD; Servidores do Estado Hospital, Recife, Pernambuco, Brazil., Carneiro APS; Servidores do Estado Hospital, Recife, Pernambuco, Brazil., Braga C; Aggeu Magalhães Institute, Oswaldo Cruz Foundation - FIOCRUZ, Recife, Pernambuco, Brazil.
Jazyk: angličtina
Zdroj: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2024 Sep; Vol. 55 (3), pp. 2643-2654. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1007/s42770-024-01382-2
Abstrakt: Objective: To describe the clinical-laboratory profile and analyze the factors associated with the severity of COVID-19.
Methods: A prospective cohort study involving patients with COVID-19 admitted to a tertiary hospital in Recife, Brazil. All cases were confirmed by RT-PCR and classified according to severity criteria. A descriptive statistical analysis of the population's characteristics was conducted. Risk factors associated with the outcome of the case according to severity were analyzed by calculating the odds ratio (OR) using the general equation estimation (GEE) model.
Results: Among the 75 cases included, 64% were female, and 62.7% were aged 65 years or older. The median length of stay was 9 days (6 - 14). Hypertension (65.3%) and Diabetes Mellitus (36%) were the most frequent comorbidities. Severe forms of COVID-19 constituted 41.3% of the sample. The factors associated with severity were a history of asthma (OR=4.58, 95%CI:1.13 - 18.7), report of anorexia (OR=1, 12, 95%CI:1.01-1.24), and laboratory changes that included elevated platelets (OR=1.00, 95% CI:1.00-1.01), elevated D'Dimer (OR=1, 26, 95% CI:1.04-1.52), elevated aspartate aminotransferase (OR=1.00, 95% CI:1.00-1.01), and gamma-glutamyl transferase (OR=1.22, IC95 %:0.98-1.51), hypernatremia (OR=1.31, 95%CI:1.12-1.52), and hyperkalemia (OR=1.21, 95% CI:1.04-1.41).
Conclusion: Multisystemic involvement with a tendency for thrombophilia, electrolyte disturbances, and hepatic aggression, reflected by laboratory changes, were factors associated with the severity of COVID-19.
(© 2024. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
Databáze: MEDLINE
Externí odkaz: