Oleaginous fungi: a promising source of biofuels and nutraceuticals with enhanced lipid production strategies.

Autor: Hassane AMA; Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, P.O. Box 71524, Assiut, Egypt. abdallahhassane@azhar.edu.eg., Eldiehy KSH; Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, P.O. Box 71524, Assiut, Egypt., Saha D; Department of Molecular Biology and Biotechnology, Tezpur University, P.O. Box 784028, Assam, India., Mohamed H; Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, P.O. Box 71524, Assiut, Egypt.; Colin Ratledge Center for Microbial Lipids, School of Agricultural Engineering and Food Science, Shandong University of Technology, P.O. Box 255000, Zibo, China., Mosa MA; Nanotechnology and Advanced Nano-Materials Laboratory (NANML), Plant Pathology Research Institute, Agricultural Research Center, P.O. Box 12619, Giza, Egypt., Abouelela ME; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, P.O. Box 11884, Cairo, Egypt., Abo-Dahab NF; Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, P.O. Box 71524, Assiut, Egypt., El-Shanawany AA; Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, P.O. Box 71524, Assiut, Egypt.
Jazyk: angličtina
Zdroj: Archives of microbiology [Arch Microbiol] 2024 Jul 02; Vol. 206 (7), pp. 338. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1007/s00203-024-04054-9
Abstrakt: Oleaginous fungi have attracted a great deal of interest for their potency to accumulate high amounts of lipids (more than 20% of biomass dry weight) and polyunsaturated fatty acids (PUFAs), which have a variety of industrial and biological applications. Lipids of plant and animal origin are related to some restrictions and thus lead to attention towards oleaginous microorganisms as reliable substitute resources. Lipids are traditionally biosynthesized intra-cellularly and involved in the building structure of a variety of cellular compartments. In oleaginous fungi, under certain conditions of elevated carbon ratio and decreased nitrogen in the growth medium, a change in metabolic pathway occurred by switching the whole central carbon metabolism to fatty acid anabolism, which subsequently resulted in high lipid accumulation. The present review illustrates the bio-lipid structure, fatty acid classes and biosynthesis within oleaginous fungi with certain key enzymes, and the advantages of oleaginous fungi over other lipid bio-sources. Qualitative and quantitative techniques for detecting the lipid accumulation capability of oleaginous microbes including visual, and analytical (convenient and non-convenient) were debated. Factors affecting lipid production, and different approaches followed to enhance the lipid content in oleaginous yeasts and fungi, including optimization, utilization of cost-effective wastes, co-culturing, as well as metabolic and genetic engineering, were discussed. A better understanding of the oleaginous fungi regarding screening, detection, and maximization of lipid content using different strategies could help to discover new potent oleaginous isolates, exploit and recycle low-cost wastes, and improve the efficiency of bio-lipids cumulation with biotechnological significance.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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