Dynamic assemblies of parvalbumin interneurons in brain oscillations.

Autor:	Huang YC; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, Taiwan., Chen HC; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, Taiwan., Lin YT; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, Taiwan., Lin ST; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, Taiwan., Zheng Q; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Abdelfattah AS; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Department of Neuroscience, Brown University, Providence, RI, USA; Carney Institute for Brain Science, Brown University, Providence, RI, USA., Lavis LD; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Schreiter ER; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Lin BJ; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. Electronic address: beijunglin@nycu.edu.tw., Chen TW; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. Electronic address: chentw@nycu.edu.tw.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2024 Aug 07; Vol. 112 (15), pp. 2600-2613.e5. Date of Electronic Publication: 2024 Jul 01.
DOI:	10.1016/j.neuron.2024.05.015
Abstrakt:	Brain oscillations are crucial for perception, memory, and behavior. Parvalbumin-expressing (PV) interneurons are critical for these oscillations, but their population dynamics remain unclear. Using voltage imaging, we simultaneously recorded membrane potentials in up to 26 PV interneurons in vivo during hippocampal ripple oscillations in mice. We found that PV cells generate ripple-frequency rhythms by forming highly dynamic cell assemblies. These assemblies exhibit rapid and significant changes from cycle to cycle, varying greatly in both size and membership. Importantly, this variability is not just random spiking failures of individual neurons. Rather, the activities of other PV cells contain significant information about whether a PV cell spikes or not in a given cycle. This coordination persists without network oscillations, and it exists in subthreshold potentials even when the cells are not spiking. Dynamic assemblies of interneurons may provide a new mechanism to modulate postsynaptic dynamics and impact cognitive functions flexibly and rapidly. Competing Interests: Declaration of interests US patents 9,933,417 and 11,091,643 and US patent application US 2021/0085805, describing azetidine-containing fluorophores and variant compositions (with inventors L.D.L. and Q.Z.), are assigned to the Howard Hughes Medical Institute (HHMI). US patent 11,385,236, describing chemigenetic voltage indicators (with inventors E.R.S., L.D.L., and A.S.A.), is assigned to HHMI. L.D.L. serves on the Cell Chemical Biology advisory board. L.D.L. is a founder and shareholder of Eikon Therapeutics. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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