Estimating an EQ-5D-Y-3L Value Set for Brazil.

Autor: Espirito Santo CM; Master's and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno, 448/475, Tatuapé, São Paulo, 03071-000, Brazil., Miyamoto GC; Master's and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno, 448/475, Tatuapé, São Paulo, 03071-000, Brazil., Santos VS; Master's and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno, 448/475, Tatuapé, São Paulo, 03071-000, Brazil., Ben ÂJ; Department of Health Sciences, Faculty of Science, Amsterdam Public Health Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Finch AP; EuroQol Research Foundation, Rotterdam, The Netherlands., Roudijk B; EuroQol Research Foundation, Rotterdam, The Netherlands., de Jesus-Moraleida FR; Master Program in Physiotherapy and Functioning, Federal University of Ceará, Fortaleza, Brazil., Stein AT; Department of Public Health, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Santos M; Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil., Yamato TP; Master's and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno, 448/475, Tatuapé, São Paulo, 03071-000, Brazil. tiparma@gmail.com.; Faculty of Medicine and Health, School of Health Sciences, The University of Sydney, Sydney, Australia. tiparma@gmail.com.; Nepean Blue Mountains Local Health District, Penrith, NSW, Australia. tiparma@gmail.com.
Jazyk: angličtina
Zdroj: PharmacoEconomics [Pharmacoeconomics] 2024 Sep; Vol. 42 (9), pp. 1047-1063. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1007/s40273-024-01404-9
Abstrakt: Introduction: The EQ-5D-Y-3L is a generic measure of health-related quality of life in children and adolescents. Although the Brazilian-Portuguese EQ-5D-Y-3L version is available, there is no value set for it, hampering its use in economic evaluations. This study aimed to elicit a Brazilian EQ-5D-Y-3L value set based on preferences of the general adult population.
Methods: Two independent samples of adults participated in an online discrete choice experiment (DCE) survey and a composite time trade-off (cTTO) face-to-face interview. The framing was "considering your views for a 10-year-old child". DCE data were analyzed using a mixed-logit model. The 243 DCE predicted values were mapped into the observed 28 cTTO values using linear and non-linear mapping approaches with and without intercept. Mapping approaches' performance was assessed to estimate the most valid method to rescale DCE predicted values using the model fit (R 2 ), Akaike Information Criteria (AIC), root mean squared error (RMSE), and mean absolute error (MAE).
Results: A representative sample of 1376 Brazilian adults participated (DCE, 1152; cTTO, 211). The linear mapping without intercept (R 2 = 96%; AIC, - 44; RMSE, 0.0803; MAE, - 0.0479) outperformed the non-linear without intercept (R 2 = 98%; AIC, - 63; RMSE, 0.1385; MAE, - 0.1320). Utilities ranged from 1 (full health) to - 0.0059 (the worst health state). Highest weights were assigned to having pain or discomfort (pain/discomfort), followed by walking about (mobility), looking after myself (self-care), doing usual activities (usual activities), and feeling worried, sad, or unhappy (anxiety/depression).
Conclusion: This study elicited the Brazilian EQ-5D-Y-3L value set using a mixed-logit DCE model with a power parameter based on a linear mapping without intercept, which can be used to estimate the quality-adjusted life-years for economic evaluations of health technologies targeting the Brazilian youth population.
(© 2024. The Author(s).)
Databáze: MEDLINE
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