Lipid Metabolism in Insect Vectors of Diseases.
| Autor: | Girotti JR; Instituto de Investigaciones Bioquímicas de La Plata (CONICET-UNLP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina. jgirotti@med.unlp.edu.ar., Calderón-Fernández GM; Instituto de Investigaciones Bioquímicas de La Plata (CONICET-UNLP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina. gcalderonf@med.unlp.edu.ar. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in experimental medicine and biology [Adv Exp Med Biol] 2024 Jun 29. Date of Electronic Publication: 2024 Jun 29. |
| DOI: | 10.1007/5584_2024_811 |
| Abstrakt: | According to the World Health Organization vector-borne diseases account for more than 17% of all infectious diseases, causing more than 700,000 deaths annually. Vectors are organisms that are able to transmit infectious pathogens between humans, or from animals to humans. Many of these vectors are hematophagous insects, which ingest the pathogen from an infected host during a blood meal, and later transmit it into a new host. Malaria, dengue, African trypanosomiasis, yellow fever, leishmaniasis, Chagas disease, and many others are examples of diseases transmitted by insects.Both the diet and the infection with pathogens trigger changes in many metabolic pathways, including lipid metabolism, compared to other insects. Blood contains mostly proteins and is very poor in lipids and carbohydrates. Thus, hematophagous insects attempt to efficiently digest and absorb diet lipids and also rely on a large de novo lipid biosynthesis based on utilization of proteins and carbohydrates as carbon source. Blood meal triggers essential physiological processes as molting, excretion, and oogenesis; therefore, lipid metabolism and utilization of lipid storage should be finely synchronized and regulated regarding that, in order to provide the necessary energy source for these events. Also, pathogens have evolved mechanisms to hijack essential lipids from the insect host by interfering in the biosynthesis, catabolism, and transport of lipids, which pose challenges to reproduction, survival, fitness, and other insect traits.In this chapter, we have tried to collect and highlight the current knowledge and recent discoveries on the metabolism of lipids in insect vectors of diseases related to the hematophagous diet and pathogen infection. (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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