The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway.

Autor: El-Sayed NS; Department of Medical Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt. norhan.mohamed@alexmed.edu.eg.; Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. norhan.mohamed@alexmed.edu.eg., Khalil NA; Department of Medical Biochemistry, Faculty of Medicine, University of Alexandria, Alexandria, Egypt., Saleh SR; Department of Biochemistry, Faculty of Science, Alexandria University, Baghdad St., Moharam Bek, Alexandria, 21511, Egypt.; Bioscreening and Preclinical Trial Lab, Department of Biochemistry, Faculty of Science, Alexandria University, Baghdad St., Moharam Bek, Alexandria, 21511, Egypt., Aly RG; Department of pathology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt., Basta M; Department of Medical Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
Jazyk: angličtina
Zdroj: Journal of molecular neuroscience : MN [J Mol Neurosci] 2024 Jul 02; Vol. 74 (3), pp. 61. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1007/s12031-024-02232-4
Abstrakt: Lifestyle influences physical and cognitive development during the period of adolescence greatly. The most important of these lifestyle factors are diet and stress. Therefore, the aim of this study was to investigate the impact of high fat diet (HFD) and chronic mild stress on cognitive function and anxiety-like behaviors in young rats and to study the role of caffeic acid as a potential treatment for anxiety and cognitive dysfunction. Forty rats were assigned into 4 groups: control, HFD, HFD + stress, and caffeic acid-treated group. Rats were sacrificed after neurobehavioral testing. We detected memory impairment and anxiety-like behavior in rats which were more exaggerated in stressed rats. Alongside the behavioral changes, there were biochemical and histological changes. HFD and/or stress decreased hippocampal brain-derived neurotrophic factor (BDNF) levels and induced oxidative and inflammatory changes in the hippocampus. In addition, they suppressed Wnt/β-catenin pathway which was associated with activation of glycogen synthase kinase 3β (GSK3β). HFD and stress increased arginase 1 and inducible nitric oxide synthase (iNOS) levels as well. These disturbances were found to be aggravated in stressed rats than HFD group. However, caffeic acid was able to reverse these deteriorations leading to memory improvement and ameliorating anxiety-like behavior. So, the current study highlights an important neuroprotective role for caffeic acid that may guard against induction of cognitive dysfunction and anxiety disorders in adolescents who are exposed to HFD and/or stress.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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