Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication.

Autor: Gaur D; Division of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA., Michalopulos MG; Division of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA., Drake KA; Division of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA., Gattineni J; Division of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA. Jyothsna.Gattineni@UTSouthwestern.edu.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1007/s00467-024-06396-4
Abstrakt: While metabolic acidosis is one of the most common complications in patients with chronic kidney disease (CKD), there are several uncommon etiologies that are challenging to diagnose. Here, we describe a patient on peritoneal dialysis who developed high anion gap metabolic acidosis secondary to acquired 5-oxoprolinemia from acetaminophen use. While CKD is a known risk factor for developing this potentially serious complication, this case further highlights how 5-oxoproline accumulation can occur, even with therapeutic dosing of acetaminophen.
(© 2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
Databáze: MEDLINE
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