Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use.

Autor:	Kirk-Provencher KT; Department of Radiology, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Aurora, CO 80045, United States., Sloan ME; Addictions Division, Centre for Addiction and Mental Health, 1001 Queen St. W, Toronto, ON, M6J 1H4, Canada.; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle Toronto, ON, M5S 1A8, Canada.; Division of Neurosciences and Clinical Translation, Department of Psychiatry, University of Toronto, 250 College St. Toronto, ON, M5T 1R8, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 620 University Ave. Toronto, ON, M5G 2C1, Canada.; Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, 1 King's College Circle Toronto, ON, M5S 1A8, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, 479 Spadina Ave. Toronto, ON, M5S 2S1, Canada., Andereas K; Department of Radiology, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Aurora, CO 80045, United States., Erickson CJ; Department of Radiology, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Aurora, CO 80045, United States., Hakimi RH; Department of Radiology, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Aurora, CO 80045, United States., Penner AE; Department of Psychiatry, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Aurora, CO 80045, United States., Gowin JL; Department of Radiology, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Aurora, CO 80045, United States.
Jazyk:	angličtina
Zdroj:	Alcohol and alcoholism (Oxford, Oxfordshire) [Alcohol Alcohol] 2024 May 14; Vol. 59 (4).
DOI:	10.1093/alcalc/agae043
Abstrakt:	Aims: Reward processing and regulation of emotions are thought to impact the development of addictive behaviors. In this study, we aimed to determine whether neural responses during reward anticipation, threat appraisal, emotion reactivity, and cognitive reappraisal predicted the transition from low-level to hazardous alcohol use over a 12-month period. Methods: Seventy-eight individuals aged 18-22 with low-level alcohol use [i.e. Alcohol Use Disorder Identification Test (AUDIT) score <7] at baseline were enrolled. They completed reward-based and emotion regulation tasks during magnetic resonance imaging to examine reward anticipation, emotional reactivity, cognitive reappraisal, and threat anticipation (in the nucleus accumbens, amygdala, superior frontal gyrus, and insula, respectively). Participants completed self-report measures at 3-, 6-, 9-, and 12-month follow-up time points to determine if they transitioned to hazardous use (as defined by AUDIT scores ≥8). Results: Of the 57 participants who completed follow-up, 14 (24.6%) transitioned to hazardous alcohol use. Higher baseline AUDIT scores were associated with greater odds of transitioning to hazardous use (odds ratio = 1.73, 95% confidence interval 1.13-2.66, P = .005). Brain activation to reward, threat, and emotion regulation was not associated with alcohol use. Of the neural variables, the amygdala response to negative imagery was numerically larger in young adults who transitioned to hazardous use (g = 0.31), but this effect was not significant. Conclusions: Baseline drinking levels were significantly associated with the transition to hazardous alcohol use. Studies with larger samples and longer follow-up should test whether the amygdala response to negative emotional imagery can be used to indicate a future transition to hazardous alcohol use. (© The Author(s) 2024. Medical Council on Alcohol and Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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