The association of diabetes with progression of sleep-disordered breathing based on a prospective cohort.

Autor: Zhang X; Department of Respiratory Medicine, Nanjing Meishan Hospital, Nanjing, China., Su Y; Department of Clinical Medicine, Nanjing Medical University, Nanjing, China., Zhu X; Department of Respiratory Medicine, Jiangsu Province Official Hospital, Nanjing, China.
Jazyk: angličtina
Zdroj: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Sep; Vol. 26 (9), pp. 3935-3939. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1111/dom.15742
Abstrakt: Aim: Prospective studies suggest that sleep-disordered breathing enhances the risk of diabetes. However, it remains unclear whether diabetes could worsen sleep-disordered breathing.
Methods: The participants from Sleep Heart Health Study underwent two polysomnograms at a 5-year interval. The relationship of baseline diabetes to change in the apnoea-hypopnoea index (AHI) was examined based on general linear models, adjusting for demographics, lifestyles, history of hypertension, pulmonary function, length of follow-up and baseline AHI.
Results: In total, 161 of the 2603 participants were diagnosed with diabetes at the first polysomnograms. Compared with participants without diabetes, those with diabetes had a higher baseline and larger increases in follow-up AHI and obstructive apnoea index (oAI). Diabetes increased 2.52 events per hour (95% confidence interval 0.45-4.59; p = .017) for AHI change and 1.13 events per hour (95% confidence interval 0.04-2.23; p = .042) for oAI change, respectively. In addition, subgroup analysis suggested that the association was consistent across baseline obstructive sleep apnoea severity and body mass index groups.
Conclusions: Baseline diabetes was associated with worsening sleep-disordered breathing over 5 years, which mainly increased the change in AHI and oAI.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: